English Version

Research

The area I put the most effort

We have consistently studied the roles of a series of biologically active substances called "autacoids". They have just intermediate properties of neurotransmitters and hormones. The target molecules of ours are 1) lipid mediators, especially arachidonic acid metabolites, and 2) bradykinins, angiotensin, and neuropeptides such as CGRP. They exhibit a variety of in vivo functions not only in the physiological conditions but also in the pathological settings. As a basic stance, we have measured a group of molecules that function in vivo, and have made a solid functional evaluation based on the time course whether they have reached meaningful concentrations or expression levels. The results of basic research should be fed back to clinical medicine, and ultimately provide seeds for drug discovery based on pathological analysis. We have to save the patients who suffer from the diseases through the outcome of the basic research. In fact, some of the achievements have already been commercialized and some have obtained international patents. We had devoted to return the scientific results to the society.

Summary of main results of research

1) Role of PGs as regulators of neovascularization

Angiogenesis is a process involved in several physiological events including embryonic development, female reproductive cycle placentation and wound repair. It also plays a part in various pathological conditions such as tumour growth, diabetic retinopathy and rheumatoid arthritis. Angiogenesis is a very complex multistep process involving a variety of biologically active substances. Of them, the prostaglandins (PGs), which can induce several growth factors and proliferation of endothelial cells in vitro and in vivo, may be crucial for enhancing neovascularization. We found using a sponge implantation model that cyclooxgenase (COX) -2 was induced to proliferating inflammatory sites, and generated PGE2 enhanced angiogenesis (1). We first identified relevant receptor signaling of PGs to the angiogenesis (2). Furthermore, we also revealed PG receptors which enhanced tumor-associated angiogenesis and tumor growth (2, 3). In a tumor model, we found that PGs up-regulated the expression of the authentic proangiogenic growth factor, vascular endothelial growth factor (VEGF) by vascular endothelial growth factor (VEGF). The site of actions of PGs were host stromal tissues judging from the results obtained in xenograft model of tumors in PG receptor knockout mice. The main findings were summarized in the review (4).

Despite the fact that the presence of lymphatic vessels has been known for over 100 years, research in lymphatics has been hampered, compared with blood vessel studies, because of the lack of adequate study tools to reveal the lymphatics. Lymphatics are sometimes eferred to as "the unknown tissues." It has been around 10~20 years that research has begun in earnest, and it is still a hot research area where new discoveries continue one after the other. We extended the angiogenesis research to lymphangiogenesis using the genetically modified mice. In a chronic proliferative inflammation model, PGs enhanced lymphangiogenesis with up-regulation in VEGF-C and VEGF-D via EP3/4 receptor signaling on macrophages (5). We also developed the secondary lymphedema model which mimics lymphedema after lymph node dissection as a part of surgical treatment of cancers (6). COX-2-derived PGs enhanced lymphangiogenesis via up-regulation of prolymphangiogenic growth factors. The application of PG ligands to treatment of edema may be promising.

In addition, we found that tumor-associate lymphangiogenesis was enhanced via EP3/4 signaling in EP receptor knockout mice (7). Further, we tested lymph node metastasis (LNM). The lymphatic system is an important route for cancer dissemination, and LNM serves as a critical prognostic determinant in cancer patients. We investigated the contribution of COX-2-derived PGE2 in the formation of a premetastatic niche and LNM (8). COX-2-expressed in dendritic cells (DCs) accumulated subcapsular regions formed a premetastatic niche. EP3 signaling elevated stromal cell-derived factor-1 (SDF-1) in DCs, and prepared the niche to adhere CXCR4-expressing tumor cells. Accumulation of Tregs and lymph node lymphangiogenesis, which may influence the fate of metastasized tumor cells, was also COX-2/EP3-dependent.

Separately, it has been reported that tumor cells mobilize immune cells and tumor-associated fibroblasts from the bone marrow and enhance cancer development by activating chemokine signals via inflammatory mediators such as PGE2 (9).

Most strong impact of our studies is that we had revealed the roles of PGs as transcriptional factors to induce the growth factors and other cytokines to facilitate the angiogenesis and the lymphangiogenesis. We changed the old concept that PGs elicited very rapid responses such as smooth muscle contractions and platelet aggregations via activation of specific G-protein coupled receptors. Further, in corporation with Ono Pharmaceutical Ltd, we found several seeds compound relevant to the therapeutics for human diseases. Besides authentic growth factors such as VEGFs, PG analogues can modulate pathological settings as small molecules.

2) Roles of arachidonic acid metabolites and COX-2 in the acute exudative inflammation

The role of arachidonic acid metabolite and bradykinin was analyzed using rat carrageenan pleurisy as a model of acute exudative inflammation. In this model, carrageenan activates the plasma kallikrein system and bradykinin is produced. Examination of arachidonic acid metabolites in the exudates revealed that 6-keto-PGF1a was detected first, and then PGE2 is produced for 1 to 5 hours after induction of inflammation. PGE2 dramatically increases blood flow at inflamed areas, increases plasma exudation from the venules, and stores pleural fluid. BK action was enhanced by PGs (10). Induction of COX-2 was seen in mononuclear cells infiltrated into the pleural cavity, and COX-2 selective inhibitors suppressed plasma exudation (11). In the acute phase, neutrophils first infiltrate into the thoracic cavity, but over time it is replaced by infiltration of mononuclear cells (12). After the acute exdudative phase of inflammation, granulation tissues were formed. This process is also COX-2-dependent.

3) Roles of kallikrein kinin system in development of salt-related hypertension

With the westernization of diet, it has become a problem in Japan how to reduce the incidence rate of cardiovascular disease. Hypertension, as a silent killer, is a lifestyle-related disease in which daily management that prevents sudden cerebral hemorrhage and myocardial infarction without particular symptoms is important. Currently, in Japan, it is said that there are 19 million affected people. We have clarified the antihypertensive effect of the kallikrein kinin system, but it is a research topic leading to the development of antihypertensive drugs with a new concept, especially antihypertensive drugs (prophylactic drugs) useful for the onset stage of hypertension. As we have already identified lead compounds, our prospects for future development are also highly expected.

Because of its strong arteriolar dilator action, kinin tends to be regarded as an antihypertensive substance through the vasodilator action. However, endogenous kinin levels in blood are only a few tenths of kinin levels that indicate antihypertensive substances, and the role of kinin in regulating blood pressure is not simple. On the other hand, in the kidney, kallikrein secreted from the distal tubule specifically degrades the kinin precursor protein kininogen molecule, which is also ejected from the tubule, to produce kinin. The generated kinin binds to the B2 receptor distributed in the collecting duct and suppresses the reabsorption of sodium at the same site. The results of this study were published in Tips and others (13, 14), but it has been clarified that the antihypertensive action of the kinin system is not due to the vasodilator action, but rather due to the increase of water sodium excretion in the kidney. Moreover, this action is exerted only when sodium is loaded or when the renin angiotensin system is enhanced. It acts like a safety valve for the living body, and suppresses the onset of high blood pressure. The Brown Norway Katholiek rat used in this study is a rat lacking the kininogen molecule. Therefore, even if kallikrein is secreted, kinin is not produced in the kidney in this mutant rats. We used this rat for the high blood pressure experiments. The in vivo function of the kinin system has been clarified by comparison with the inbred normal rat Brown Norway Kitasato rat bearing the name of Kitasato.

In addition to kinin, antihypertensive effects of PG were also examined. It has been found that inducible COX-2, which has hitherto been considered to have no expression in the kidney, plays a major role in the increase of renin release in a renovascular hypertension model (15).

4) Suppressions of gastric mucosal damages by PGs and a neuropeptide, CGRP

When high concentration of ethanol (Et-OH) is administered to the mouse gastric lumen, gastric mucosal damages that are recognized as a red color is introduced. Intrabital microscopic observation revealed that the mucosal damages are not "bleeding", but "congestion" of the mucsae caused by contraction of the collecting venules (16). Gastric mucosal mast cell-derived leukotriene C4 causes constriction of collecting venules (17).

Et-OH-induced gastric mucosal injury can be suppressed by administration of capsaicin, which is a pungent component of red pepper, to the gastric lumen. Capsaicin releases neuropeptide substance P and calcitonin gene-related peptide (CGRP) from sensory nerve terminals. Among them, CGRP is abundantly released and suppresses mucosal damages (18).

Also, raising the osmotic pressure of the gastric lumen produces prostaglandins (PG) I2 and E2 within the gastric wall. Although 1 M NaCl solution is used experimentally, even after Et-OH is exposed to the stomach after gastric stimulation, gastric mucosal injury is strongly suppressed as with capsaicin (16). PG produced by 1 M NaCl solution has the action to suppress both tetragastrin-stimulated gastric acid secretion and reflex of gastric smooth muscle contraction in the gastric wall. Further, PG produced by 1 M NaCl solution acts as a "neuromodulator" to increase the released amount of CGRP during Et-OH administration (19). Relevant PG is PGI2 when estimated by prostanoid receptor knock mice. The entire digestive tract contains a number of nerve cells comparable to the central nervous system. The results of our studies support the importance of CGRP nerve systems as a biological defense system (neural emergency system) in the digestive tracts.

We recently found that CGRP was proangiogenic and prolymphangiogenic, and had a modulating activity in pathological conditions (20, 21, 22). The activity of CGRP to regulate neovascularization was summarized in our recent review article (23).

5) Study of the organ microcirculation

The occurrence of liver damage such as liver ischemia reperfusion and endotoxemia is considered to be dependent to the dysfunction of liver microcirculation. We developed the methods to see the hepatic microcirculation in mice, and estimated hepatic microvessel responses to vasoactive substances, endotoxin, and cytokines. Inflammatory cytokines (TNF, IL-1) were involved in hepatic microcirculatory disorders (24). In endotoxin hypersensitive mice, adhesion of leukocytes to the hepatic sinusoid was increased, and sinusoidal perfusion was reduced. These reactions were accompanied with increase in serum GPT levels, and increase in blood TNFα and IL-1 levels. Adhesion of leukocytes to hepatic sinusoid was mediated by LFA-1 and ICAM-1. Inhibiting the production of TNFα and IL-1 in endotoxin-sensitive mice significantly suppressed adhesion of leukocytes to the hepatic sinusoid, decrease in sinusoidal perfusion, and increase in serum GTP levels.

In addition, we are investigating the involvement of neutrophil elastase in this model and the involvement of prostaglandins. In particular, the latter has been investigated using prostanoid receptor-deficient mice (25).

In addition to endotoxin eperiments, liver ischemia reperfusion (partial liver partial ischemia) was performed, and liver microcirculation was observed using an intravital microscopes. Macrophages and other types of immune cells modulated hepatic functions, and repair process from the damages. The role of PG and LT in liver damage repair has also been estimated in several models (26, 27).

Reference

Majima M, Hayashi I, Muramatsu M, Katada J, Yamashina S, Katori M. Cyclo-oxygenase-2 enhances basic fibroblast growth factor-induced angiogenesis through induction of vascular endothelial growth factor in rat sponge implants. Br J Pharmacol. 2000 Jun;130(3):641-9.
Amano H, Hayashi I, Endo H, Kitasato H, Yamashina S, Maruyama T, Kobayashi M, Satoh K, Narita M, Sugimoto Y, Murata T, Yoshimura H, Narumiya S, Majima M. Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. J Exp Med. 2003 Jan 20;197(2):221-32.
Yoshida S, Amano H, Hayashi I, Kitasato H, Kamata M, Inukai M, Yoshimura H, Majima M. COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo. Lab Invest. 2003 Oct;83(10):1385-94.
Majima M, Amano H, Hayashi I. Prostanoid receptor signaling relevant to tumor growth and angiogenesis. Trends Pharmacol Sci. 2003 Oct;24(10):524-9.
Hosono K, Suzuki T, Tamaki H, Sakagami H, Hayashi I, Narumiya S, Alitalo K, Majima M. Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation. Arterioscler Thromb Vasc Biol. 2011 May;31(5):1049-58. doi: 10.1161/ATVBAHA.110.222356.
Kashiwagi S, Hosono K, Suzuki T, Takeda A, Uchinuma E, Majima M. Role of COX-2 in lymphangiogenesis and restoration of lymphatic flow in secondary lymphedema. Lab Invest. 2011 Sep;91(9):1314-25. doi: 10.1038/labinvest.2011.84.
Kubo H, Hosono K, Suzuki T, Ogawa Y, Kato H, Kamata H, Ito Y, Amano H, Kato T, Sakagami H, Hayashi I, Sugimoto Y, Narumiya S, Watanabe M, Majima M. Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis. Biomed Pharmacother. 2010 Feb;64(2):101-6. doi: 10.1016/j.biopha.2009.04.039.
Ogawa F, Amano H, Eshima K, Ito Y, Matsui Y, Hosono K, Kitasato H, Iyoda A, Iwabuchi K, Kumagai Y, Satoh Y, Narumiya S, Majima M. Prostanoid induces premetastatic niche in regional lymph nodes. J Clin Invest. 2014 Nov;124(11):4882-94. doi: 10.1172/JCI73530.
Katoh H, Hosono K, Ito Y, Suzuki T, Ogawa Y, Kubo H, Kamata H, Mishima T, Tamaki H, Sakagami H, Sugimoto Y, Narumiya S, Watanabe M, Majima M. COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems. Am J Pathol. 2010 Mar;176(3):1469-83. doi: 10.2353/ajpath.2010.090607.
Katori M, Majima M. Cyclooxygenase-2: its rich diversity of roles and possible application of its selective inhibitors. Inflamm Res. 2000 Aug;49(8):367-92.
Katori M, Harada Y, Hatanaka K, Majima M, Kawamura M, Ohno T, Aizawa A, Yamamoto S. Induction of prostaglandin H synthase-2 in rat carrageenin-induced pleurisy and effect of a selective COX-2 inhibitor. Adv Prostaglandin Thromboxane Leukot Res. 1995;23:345-7.
Ogino M, Majima M, Kawamura M, Hatanaka K, Saito M, Harada Y, Katori M. Increased migration of neutrophils to granulocyte-colony stimulating factor in rat carrageenin-induced pleurisy: roles of complement, bradykinin, and inducible cyclooxygenase-2. Inflamm Res. 1996 Jul;45(7):335-46.
Majima M, Katori M. Approaches to the development of novel antihypertensiven drugs: crucial role of the renal kallikrein-kinin system. Trends Pharmacol Sci. 1995 Jul;16(7):239-46.
Katori M, Majima M. The renal kallikrein-kinin system: its role as a safety valve for excess sodium intake, and its attenuation as a possible etiologic factor in salt-sensitive hypertension. Crit Rev Clin Lab Sci. 2003 Feb;40(1):43-115.
Okumura T, Hayashi I, Ikezawa T, Yamanaka M, Takata T, Fujita Y, Saigenji K, Yamashina S, Majima M. Cyclooxygenase-2 inhibitors attenuate increased blood pressure in renovascular hypertensive models, but not in deoxycorticosterone-salt hypertension. Hypertens Res. 2002 Nov;25(6):927-38.
Boku K, Ohno T, Saeki T, Hayashi H, Hayashi I, Katori M, Murata T, Narumiya S, Saigenji K, Majima M. Adaptive cytoprotection mediated by prostaglandin I(2) is attributable to sensitization of CRGP-containing sensory nerves. Gastroenterology. 2001 Jan;120(1):134-43.
Hattori Y, Ohno T, Ae T, Saeki T, Arai K, Mizuguchi S, Saigenji K, Majima M. Gastric mucosal protection against ethanol by EP2 and EP4 signaling through the inhibition of leukotriene C4 production. Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G80-7.
Saeki T, Ohno T, Boku K, Saigenji K, Katori M, Majima M. Mechanism of prevention by capsaicin of ethanol-induced gastric mucosal injury--a study in the rat using intravital microscopy. Aliment Pharmacol Ther. 2000 Apr;14 Suppl 1:135-44.
Arai K, Ohno T, Saeki T, Mizuguchi S, Kamata K, Hayashi I, Saigenji K, Murata T, Narumiya S, Majima M. Endogenous prostaglandin I2 regulates the neural emergency system through release of calcitonin gene related peptide. Gut. 2003 Sep;52(9):1242-9.
Toda M, Suzuki T, Hosono K, Hayashi I, Hashiba S, Onuma Y, Amano H, Kurihara Y, Kurihara H, Okamoto H, Hoka S, Majima M. Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide. Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13550-5. doi: 10.1073/pnas.0800767105.
Ohno T, Hattori Y, Komine R, Ae T, Mizuguchi S, Arai K, Saeki T, Suzuki T, Hosono K, Hayashi I, Oh-Hashi Y, Kurihara Y, Kurihara H, Amagase K, Okabe S, Saigenji K, Majia M. Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis. Gastroenterology. 2008 Jan;134(1):215-25.
Kurashige C, Hosono K, Matsuda H, Tsujikawa K, Okamoto H, Majima M. Roles of receptor activity-modifying protein 1 in angiogenesis and lymphangiogenesis during skin wound healing in mice. FASEB J. 2014 Mar;28(3):1237-47. doi: 10.1096/fj.13-238998.
Majima M, Ito Y, Hosono K, Amano H. CGRP/CGRP Receptor Antibodies: Potential Adverse Effects Due to Blockade of Neovascularization? Trends Pharmacol Sci. 2019 Jan;40(1):11-21. doi: 10.1016/j.tips.2018.11.003.
Matsumoto Y, Ito Y, Hayashi I, Majima M, Ishii K, Katagiri H, Kakita A. Effect of FR167653, a novel inhibitor of tumor necrosis factor-alpha and interleukin-1beta synthesis on lipopolysaccharide-induced hepatic microvascular dysfunction in mice. Shock. 2002 May;17(5):411-5.
Katagiri H, Ito Y, Ishii K, Hayashi I, Suematsu M, Yamashina S, Murata T, Narumiya S, Kakita A, Majima M. Role of thromboxane derived from COX-1 and -2 in hepatic microcirculatory dysfunction during endotoxemia in mice. Hepatology. 2004 Jan;39(1):139-50.
Nishizawa N, Ito Y, Eshima K, Ohkubo H, Kojo K, Inoue T, Raouf J, Jakobsson PJ, Uematsu S, Akira S, Narumiya S, Watanabe M, Majima M. Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice. J Hepatol. 2018 Jul;69(1):110-120. doi: 10.1016/j.jhep.2018.02.009.
Ohkubo H, Ito Y, Minamino T, Mishima T, Hirata M, Hosono K, Shibuya M, Yokomizo T, Shimizu T, Watanabe M, Majima M. Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment. FASEB J. 2013 Aug;27(8):3132-43. doi: 10.1096/fj.13-227421.

Brief CV

Name; Masataka Majima

Sex; Male

Birthday; April 22, 1954

Nationality; Japan

Present Position; Dean, School of Health and Medical Sciences, Kanagawa Institute of Technology (KAIT)

Address; Academia; 1030 Shimo-Ogino, Atsugi, Kanagawa 243-0292, Japan

Tel; +81-46-206-0214

e-mail; mmajima@cet.kanagwa-it.ac.jp

Education and Research

March 31, 1981 Chiba University School of Medicine (MD)

March 31, 1985 Kitasato Graduate School of Medicine (PhD)

April 1, 1985 Assistant of Professor (Dept. of Pharmacology, Kitasato

University School of Medicine)

April 1, 1991 Lecturer (Dept. of Pharmacology, Kitasato

University School of Medicine)

August 1, 1995 Research Fellow (Dept. of Vascular disease and

hypertension, Henry Ford Hospital, Michigan)

May 1, 1996 Professor and Chair (Dept. of Pharmacology, Kitasato

University School of Medicine)

October 1, 2005 Vice Dean (Research Affairs, Kitasato University

School of Medicine)

July 1, 2014 Dean (Graduate School of Medical Sciences, Kitasato University)

Sept 1, 2016 Vice President of Kitasato University (Research Affairs and International Exchange)

April 1, 2019 Visiting Professor (Kanagawa Institute of Technology)

April 1, 2020 Dean, School of Health and Medical Sciences, (Kanagawa Institute of Technology)

Prize

JJP Prize, 1999

Shibasaburou Kitasato Memorial Award, 2000

Tojyu Hata Cancer Award, 2005

Takeda Research Award, 2010

Uehara Memorial Foundation Award, 2014

Membership

Japanese Inflammation and Regeneration Society (Executive

Member)

Japanese Pharmacological Society (Executive Member)

Japanese Lymphology Society (Executive Member)

Japanese Microcirculation Society (Executive Member)

Japanese Shock Society (Executive Member)

Selected publications

Matsuda H, Ito Y, Hosono K, Tsuru S, Inoue T, Nakamoto S, Kurashige C, Hirashima M, Narumiya S, Okamoto H, Majima M. Roles of Thromboxane Receptor Signaling in Enhancement of Lipopolysaccharide-Induced Lymphangiogenesis and Lymphatic Drainage Function in Diaphragm. Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1390-1407. doi: 10.1161/ATVBAHA.120.315507. Epub 2021 Feb 11. PMID: 33567865.
Sekiguchi K, Ito Y, Hattori K, Inoue T, Hosono K, Honda M, Numao A, Amano H, Shibuya M, Unno N, Majima M. VEGF Receptor 1-Expressing Macrophages Recruited from Bone Marrow Enhances Angiogenesis in Endometrial Tissues. Sci Rep. 2019 May 7;9(1):7037. doi: 10.1038/s41598-019-43185-8.
Majima M, Ito Y, Hosono K, Amano H. CGRP/CGRP Receptor Antibodies: Potential Adverse Effects Due to Blockade of Neovascularization? Trends Pharmacol Sci. 2019 Jan;40(1):11-21. doi: 10.1016/j.tips.2018.11.003.
Nishizawa N, Ito Y, Eshima K, Ohkubo H, Kojo K, Inoue T, Raouf J, Jakobsson PJ, Uematsu S, Akira S, Narumiya S, Watanabe M, Majima M. Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice. J Hepatol. 2018 Feb 16. pii: S0168-8278(18)30126-0.
Hosono K, Isonaka R, Kawakami T, Narumiya S, Majima M. Signaling of Prostaglandin E Receptors, EP3 and EP4 Facilitates Wound Healing and Lymphangiogenesis with Enhanced Recruitment of M2 Macrophages in Mice. PLoS One. 2016 Oct 6;11(10):e0162532. doi: 10.1371/journal.pone.0162532. PubMed PMID:27711210.
Kojo K, Ito Y, Eshima K, Nishizawa N, Ohkubo H, Yokomizo T, Shimizu T, Watanabe M, Majima M. BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils. Sci Rep. 2016 Jul 11;6:29650. doi: 10.1038/srep29650. PubMed PMID: 27404729; PubMed Central PMCID: PMC4939602.
Okizaki S, Ito Y, Hosono K, Oba K, Ohkubo H, Kojo K, Nishizawa N, Shibuya M, Shichiri M, Majima M. Vascular Endothelial Growth Factor Receptor Type 1 Signaling Prevents Delayed Wound Healing in Diabetes by Attenuating the Production of IL-1β by Recruited Macrophages. Am J Pathol. 2016 Jun;186(6):1481-98. doi: 10.1016/j.ajpath.2016.02.014. Epub 2016 Apr 13. PubMed PMID: 27085138.
Fujita T, Soontrapa K, Ito Y, Iwaisako K, Moniaga CS, Asagiri M, Majima M, Narumiya S. Hepatic stellate cells relay inflammation signaling from sinusoids to parenchyma in mouse models of immune-mediated hepatitis. Hepatology. 2016 Apr;63(4):1325-39. doi: 10.1002/hep.28112. Epub 2015 Sep 30. PubMed PMID:26248612.
Amano H, Ito Y, Eshima K, Kato S, Ogawa F, Hosono K, Oba K, Tamaki H, Sakagami H, Shibuya M, Narumiya S, Majima M. Thromboxane A2 induces blood flow recovery via platelet adhesion to ischaemic regions. Cardiovasc Res. 2015 Sep 1;107(4):509-21. doi: 10.1093/cvr/cvv139. Epub 2015 May 1. PubMed PMID: 25935870.
H. Amano, S. Kato, Y. Ito, R. Takahashi, K. Eshima, K Sakaguchi, H. Tamaki, H. Sakagami, F. Ogawa, M. Shibuya, M. Majima. Roles of vascular endothelial growth factor receptor 1 signaling in recovery from ischemia. PLoS One 2015 in press.
Matsui Y, Amano H, Ito Y, Eshima K, Tamaki H, Ogawa F, Iyoda A, Shibuya M, Kumagai Y, Satoh Y, Majima M.  The role of vascular endothelial growth factor receptor-1 signaling in compensatory contralateral lung growth following unilateral pneumonectomy.  Laboratory Investigation. 2015 Feb 2. doi: 10.1038/labinvest.2014.159. [Epub ahead of print] PMID: 25642830
Ogawa F, Amano H, Eshima Y, Ito Y, Matsui Y, Hosono K, Kitasato H, Iyoda A, Iwabuchi K, Kumagai Y, Satoh Y, Narumiiya S, Majima M. Prostanoid induces premetastatic niche in regional lymph nodes.   J. Clin. Invest. 2014 Nov 3;124(11):4882-94. doi: 10.1172/JCI73530. Epub 2014 Oct 1. PMID: 25271626
Ohkubo H, Ito Y, Minamino T, Eshima K, Kojo K, Okizaki S, Hirata M, Shibuya M, Watanabe M, Majima M.  VEGFR1-positive macrophages facilitate liver repair and sinusoidal reconstruction after hepatic ischemia/reperfusion injury. PLoS One 2014 Aug 27;9(8):e105533. doi: 10.1371/journal.pone.0105533. eCollection 2014. PMID: 25162491
Kurashige C, Hosono K, Matsuda H, Tsujikawa K, Okamoto H, Majima M. Roles of receptor activity-modifying protein 1 in angiogenesis and lymphangiogenesis during skin wound healing in mice. FASEB J. 2014 Mar;28(3):1237-47. doi: 10.1096/fj.13-238998. Epub 2013 Dec 5. PMID: 24308973
Ohkubo H, Ito Y, Minamino T, Mishima T, Hirata M, Hosono K, Shibuya M, Yokomizo T, Shimizu T, Watanabe M, Majima M.  Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment. FASEB J. 2013 Aug;27(8):3132-43. doi: 10.1096/fj.13-227421. Epub 2013 Apr 29. PMID: 23629862
Amano H, Ito Y, Ogawa F, Eshima K, Suzuki T, Oba K, Matsui Y, Kato S, Fukui T, Nakamura M, Kitasato H, Fukamizu A, Majima M. Angiotensin II type 1a signaling facilitates tumor metastasis formation through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells. Am J Pathol. 2013 Feb;182(2):553-64. doi: 10.1016/j.ajpath.2012.10.026. Epub 2012 Dec 3. PMID: 23219751
Minamino T, Ito Y, Ohkubo H, Hosono K, Suzuki T, Sato T, Ae T, Shibuya A, Sakagami H, Narumiya S, Koizumi W, Majima M. Thromboxane A(2) receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment. Toxicol Appl Pharmacol. 2012;259(1):104-14.
Kashiwagi S, Hosono K, Majima M, et al. Role of COX-2 in lymphangiogenesis and restoration of lymphatic flow in secondary lymphedema. Lab Invest. 2011;91(9):1314-25.
Hosono K, Majima M, et al. Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation. Arterioscler Thromb Vasc Biol. 2011;31(5):1049-58.
Kato T, Ito Y, Hosono K, Majima M, , et al. Vascular endothelial growth factor receptor-1 signaling promotes liver repair through restoration of liver microvasculature after acetaminophen hepatotoxicity. Toxicol Sci. 2011;120(1):218-29.
Mishima M, Ito Y, Hosono K, Majima M, et al. Roles of calcitonin gene-related peptide in the facilitation of angiogenesis during hindlimb ischemia in mice. Am J Physiol Heart Circulatory Physiol. 2011;300(2):H431-9.
Ae T, Hosono K, Majima M, et al. Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers. Am J Physiol Gastrointest Liver Physiol. 2010;299(5):G1139-46.
Katoh H, Hosono K, Ito Y, Suzuki T, Ogawa Y, Kubo H, Kamata H, Mishima T, Tamaki H, Sakagami H, Sugimoto Y, Narumiya S, Watanabe M, Majima M. COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems. Am J Pathol. 2010;176(3):1469-83.
Toda M, Suzuki T, Hosono K, Hayashi I, Hashiba S, Onuma Y, Amano H, Kurihara Y, Kurihara H, Okamoto H, Hoka S, Majima M. Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide. Proc Natl Acad Sci U S A. 2008;105(36):13550-5.
Ohno T, Komine R, Hattori Y, Mizuguchi S, Arai K, Saeki T, Oh-hashi Y, Kurihara Y, Kurihara H, Amagase K, Okabe S, Saigenji K, Majima M. Roles of Calcitonin Gene-related Peptide in Maintenance of Gastric Mucosal Integrity and in Enhancement of Ulcer Healing and Angiogenesis. Gastroenterology 2008; 134(1):215-25.
Kamoshita E, Ikeda Y, Fujita M, Amano H, Oikawa A, Suzuki T, Ogawa Y, Yamashina S, Azuma S, Narumiya S, Unno N, Majima M. Recruitment of a prostaglandin E receptor subtype, EP3-expressing bone marrow cells is crucial in wound-induced angiogenesis. Am J Pathol. 2006;169(4):1458-72.
Fujita M, Majima M, et al. Angiotensin Type 1a Receptor Signaling-dependent Induction of Vascular Endothelial Growth Factor in Stroma is Relevant to Tumor-associated Angiogenesis and Tumor Growth. Carcinogenesis. 2005;26(2):271-9.
Kobayashi T, Majima M, et al. Roles of thromboxane A(2) and prostacyclin in the development of atherosclerosis in apoE-deficient mice. J Clin Invest. 2004;114(6):784-794.
Ikeda Y, Hayashi I, Kamoshita E, Yamazaki A, Endo H, Ishihara K, Yamashina S, Tsutsumi Y, Matsubara H, Majima M. Host stromal bradykinin B2 receptor signaling facilitates tumor-associated angiogenesis and tumor growth. Cancer Res. 2004;64(15):5178-85.
Katagiri H, Ito Y, Ishii K, Hayashi I, Suematsu M, Yamashina S, Murata T, Narumiya S, Kakita A, Majima M. Role of thromboxane derived from COX-1 and -2 in hepatic microcirculatory dysfunction during endotoxemia in mice. Hepatology. 2004;39(1):139-50.
Majima M, Amano H, Hayashi I. Prostanoid receptor signaling relevant to tumor growth and angiogenesis. Trends Pharmacol Sci. 2003;24(10):524-9.
Yoshida S, Majima M, et al. COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo. Lab Invest. 2003; 83(10):1385-94.
Arai K, Ohno T, Saeki T, Mizuguchi S, Kamata K, Hayashi I, Saigenji K, Murata T, Narumiya S, Majima M. Endogenous prostaglandin I2 regulates the neural emergency system through release of calcitonin gene related peptide. Gut 2003;52(9):1242-9.
Amano H, Hayashi I, Endo H, Kitasato H, Yamashina S, Maruyama T, Kobayashi M, Satoh K, Narita M, Sugimoto Y, Murata T, Yoshimura H, Narumiya S, Majima M. Host prostaglandin E2-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. J Exp Med. 2003;197(2):221-32.
Ando M, Majima M, et al. Retrovirally introduced prostaglandin D2 synthase suppresses lung injury induced by bleomycin. Am J Respir Cell Mol Biol. 2003;28(5):582-91.
Boku K, Ohno T, Saeki T, Hayashi H, Hayashi I, Katori M, Murata T, Narumiya S, Saigenji K, Majima M. Adaptive cytoprotection mediated by prostaglandin I2 is attributable to sensitization of CRGP-containing sensory nerves. Gastroenterology. 2001;120(1): 134-43.
Muramatsu M, Katada J, Hayashi I, Majima M. Chymase as a proangiogenic factor. A possible involvement of chymase-angiotensin-dependent pathway in the hamster sponge angiogenesis model. J Biol Chem. 2000;275(8):5545-52.
Majima M, Katori M. Approaches to the development of novel antihypertensive drugs: crucial role of the renal kallikrein-kinin system. Trends Pharmacol Sci. 1995;16(7):239-46.
Majima M, Mizogami S, Kuribayashi Y, Katori M, Oh-ishi S. Hypertension induced by a nonpressor dose of angiotensin II in kininogen-deficient rats. Hypertension. 1994;24(1):111-9.
Majima M, Yoshida O, Mihara H, Muto T, Mizogami S, Kuribayashi Y, Katori M, Oh-ishi S. High sensitivity to salt in kininogen-deficient brown Norway Katholiek rats. Hypertension. 1993;22(5):705-14.

Monographs

A Textbook of Pharmacology (Standard Pharmacology), Igakushoin, Tokyo, 2002.
A Textbook of Pharmacology (Medical Pharmacology), Nanzandou, Tokyo, 2004.
A Textbook of Pharmacology (New Pharmacology), Nankoudou, Tokyo, 2006.
Advances in Pharmocology, Renal kallikrein kinin system as a preventive factor of salt-sensitive hypertension, Academic Press, 1997.

Major Interests in Science

Regulation of angiogenesis, lymphangiogenesis, and fibrosis by inflammatory mediators.
Analysis and regulation of microcirculation in important organs.
Sodium and water handling during development of experimental hypertension.
Clinical Pharmacology including drug transporter and microdosing.

Full publication list

Majima M, Matsuda Y, Watanabe SI, Ohtaki Y, Hosono K, Ito Y, Amano H. Prostanoids Regulate Angiogenesis and Lymphangiogenesis in Pathological Conditions. Cold Spring Harb Perspect Med. 2024 Apr 2:a041182. doi: 10.1101/cshperspect.a041182. Epub ahead of print. PMID: 38565267.
Hosono K, Yamashita A, Tanabe M, Ito Y, Majima M, Tsujikawa K, Amano H. Deletion of RAMP1 Signaling Enhances Diet-induced Obesity and Fat Absorption via Intestinal Lacteals in Mice. In Vivo. 2024 Jan-Feb;38(1):160-173. doi: 10.21873/invivo.13422. PMID: 38148085.
Furue A, Hattori K, Hosono K, Tanabe M, Sato E, Honda M, Sekiguchi K, Ito Y, Majima M, Narumiya S, Kato K, Amano H. Inhibition of TP signaling promotes endometriosis growth and neovascularization. Mol Med Rep. 2023 Oct;28(4):192. doi: 10.3892/mmr.2023.13079. Epub 2023 Sep 1. PMID: 37654213.
Majima M, Hosono K, Ito Y, Amano H, Nagashima Y, Matsuda Y, Watanabe SI, Nishimura H. A biologically active lipid, thromboxane, as a regulator of angiogenesis and lymphangiogenesis. Biomed Pharmacother. 2023 Jul;163:114831. doi: 10.1016/j.biopha.2023.114831. Epub 2023 May 8. PMID: 37150029.
Otaka F, Ito Y, Nakamoto S, Nishizawa N, Hyodo T, Hosono K, Majima M, Koizumi W, Amano H. Macrophages contribute to liver repair after monocrotaline-induced liver injury via SDF-1/CXCR4. 2021 Jul;22(1):668. doi: 10.3892/etm.2021.10100. Epub 2021 Apr 22. PMID: 33986833; PMCID: PMC8112113.
Matsuda H, Ito Y, Hosono K, Tsuru S, Inoue T, Nakamoto S, Kurashige C, Hirashima M, Narumiya S, Okamoto H, Majima M. Roles of Thromboxane Receptor Signaling in Enhancement of Lipopolysaccharide-Induced Lymphangiogenesis and Lymphatic Drainage Function in Diaphragm. Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1390-1407. doi: 10.1161/ATVBAHA.120.315507. Epub 2021 Feb 11. PMID: 33567865.
Otaka F, Ito Y, Goto T, Eshima K, Amano H, Koizumi W, Majima M. Platelets prevent the development of monocrotaline-induced liver injury in mice. Toxicol Lett. 2020 Oct 22;335:71-81. doi: 10.1016/j.toxlet.2020.10.007. Online ahead of print.
Honda M, Ito Y, Hattori K, Hosono K, Sekiguchi K, Tsujikawa K, Unno N, Majima M. Inhibition of receptor activity-modifying protein 1 suppresses the development of endometriosis and formation of blood/lymphatic vessels. J. Cell. Mol. Med. 2020 Oct;24(20):11984-11997. doi: 10.1111/jcmm.15823.
Hosono K, Kojo K, Narumiya S, Majima M, Ito Y. Prostaglandin E receptor EP4 stimulates lymphangiogenesis to promote mucosal healing during DSS-induced colitis. Biomed Pharmacother. 2020 May 21;128:110264. doi: 10.1016/j.biopha.2020.110264.
Hattori K, Ito Y, Honda M, Sekiguchi K, Hosono K, Shibuya M, Unno N, Majima M.Lymphangiogenesis induced by vascular endothelial growth factor receptor 1 signaling contributes to the progression of endometriosis in mice. J Pharmacol Sci. 2020 May 16:S1347-8613(20)30047-5. doi: 10.1016/j.jphs.2020.05.003.
Nakamoto S, Ito Y, Nishizawa N, Goto T, Kojo K, Kumamoto Y, Watanabe M, Majima M. Lymphangiogenesis and accumulation of reparative macrophages contribute to liver repair after hepatic ischemia-reperfusion injury. Angiogenesis. 2020 Mar 11. doi: 10.1007/s10456-020-09718-w.
Nakamoto S, Ito Y, Nishizawa N, Goto T, Kojo K, Kumamoto Y, Watanabe M, Narumiya S, Majima M. EP3 signaling in dendritic cells promotes liver repair by inducing IL-13-mediated macrophage differentiation in mice. FASEB J. 2020 Apr;34(4):5610-5627. doi: 10.1096/fj.201901955R.
Tsuru S, Ito Y, Matsuda H, Hosono K, Inoue T, Nakamoto S, Kurashige C, Mishima T, Tsujikawa K, Okamoto H, Majima M. RAMP1 signaling in immune cells regulates inflammation-associated lymphangiogenesis. Lab Invest. 2020 May;100(5):738-750. doi: 10.1038/s41374-019-0364-0.
Takahashi R, Amano H, Ito Y, Eshima K, Satoh T, Iwamura M, Nakamura M, Kitasato H, Uematsu S, Raouf J, Jakobsson PJ, Akira S, Majima M. Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b+Gr1+MDSCs from bone marrow. Biomed Pharmacother. 2020 Jan;121:109581. doi: 10.1016/j.biopha.2019.109581.
Otaka F, Ito Y, Inoue T, Ohkubo H, Nishizawa N, Kojo K, Betto T, Yamane S, Narumiya S, Koizumi W, Majima M. Thromboxane A(2) receptor signaling in endothelial cells attenuates monocrotaline-induced liver injury. Toxicol Appl Pharmacol. 2019 Aug 27;381:114733. doi: 10.1016/j.taap.2019.114733.
Amano H, Mastui Y, Ito Y, Shibata Y, Betto T, Eshima K, Ogawa F, Satoh Y, Shibuya M, Majima M. The role of vascular endothelial growth factor receptor 1 tyrosine kinase signaling in bleomycin-induced pulmonary fibrosis. Biomed. Pharmacother. 2019 Jun 5;117:109067. doi:10.1016/j.biopha.2019.109067.
Sekiguchi K, Ito Y, Hattori K, Inoue T, Hosono K, Honda M, Numao A, Amano H, Shibuya M, Unno N, Majima M. VEGF Receptor 1-Expressing Macrophages Recruited from Bone Marrow Enhances Angiogenesis in Endometrial Tissues. Sci. Rep. 2019 May 7;9(1):7037. doi: 10.1038/s41598-019-43185-8.
Kamata M, Amano H, Ito Y, Fujita T, Otaka F, Hosono K, Kamata K, Takeuchi Y, Yokomizo T, Shimizu T, Majima M. Role of the high-affinity leukotriene B4 receptor signaling in fibrosis after unilateral ureteral obstruction in mice. PLoS One. 2019 Feb 28;14(2):e0202842. doi: 10.1371/journal.pone.0202842.
Betto T, Amano H, Ito Y, Eshima K, Yoshida T, Matsui Y, Yamane S, Inoue T, Otaka F, Kobayashi K, Koizumi W, Shibuya M, Majima M. Vascular endothelial growth factor receptor 1 tyrosine kinase signaling facilitates healing of DSS-induced colitis by accumulation of Tregs in ulcer area. Biomed. Pharmacother. 2019 Mar;111:131-141. doi: 10.1016/j.biopha.2018.12.021.
Majima M, Ito Y, Hosono K, Amano H. CGRP/CGRP Receptor Antibodies: Potential Adverse Effects Due to Blockade of Neovascularization? Trends Pharmacol. Sci. 2019 Jan;40(1):11-21. doi: 10.1016/j.tips.2018.11.003.
Inoue T, Ito Y, Nishizawa N, Eshima K, Kojo K, Otaka F, Betto T, Yamane S, Tsujikawa K, Koizumi W, Majima M. RAMP1 in Kupffer cells is a critical regulator in immune-mediated hepatitis. PLoS One. 2018 Nov 21;13(11):e0200432. doi: 10.1371/journal.pone.0200432.
Nishizawa N, Ito Y, Eshima K, Ohkubo H, Kojo K, Inoue T, Raouf J, Jakobsson PJ, Uematsu S, Akira S, Narumiya S, Watanabe M, Majima M. Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice. J. Hepatol. 2018 Feb 16. pii: S0168-8278(18)30126-0.
Park K, Amano H, Ito Y, Mastui Y, Kamata M, Yamazaki Y, Takeda A, Shibuya M, Majima M. Vascular endothelial growth factor receptor 1 (VEGFR1) tyrosine kinase signaling facilitates granulation tissue formation with recruitment of VEGFR1(+) cells from bone marrow. Anat. Sci. Int. 2017 Dec 18.
Mishima T, Ito Y, Nishizawa N, Amano H, Tsujikawa K, Miyaji K, Watanabe M, Majima M. RAMP1 signaling improves lymphedema and promotes lymphangiogenesis in mice. J. Surg. Res. 2017 Nov;219:50-60.
Shimizu Y, Amano H, Ito Y, Betto T, Yamane S, Inoue T, Nishizawa N, Matsui Y, Kamata M, Nakamura M, Kitasato H, Koizumi W, Majima M. Angiotensin II subtype 1a receptor signaling in resident hepatic macrophages induces liver metastasis formation. Cancer Sci. 2017 Sep;108(9):1757-1768.
Shimizu Y, Amano H, Ito Y, Betto T, Yamane S, Inoue T, Nishizawa N, Kamata M, Koizumi W, Majima M. The role of angiotensin II in liver metastasis formation from colorectal cancer. KMJ 2017 Mar;47(1): 43-51.
Nakamura M, Kagawa L, Nakada N, Satoh M, Maehara S, Kojima F, Amano H, Murakumo Y, Iwabuchi K, Majima M, Kitasato H. Anti-tumor effects of interferon-beta cell therapy in murine model of melanoma. Int. J. Cancer Ther. Oncol. 2016 Oct-Dec; 4(4): 4412-4422. DOI: 10.14319/ijcto.44.12.
Hosono K, Isonaka R, Kawakami T, Narumiya S, Majima M. Signaling of Prostaglandin E Receptors, EP3 and EP4 Facilitates Wound Healing and Lymphangiogenesis with Enhanced Recruitment of M2 Macrophages in Mice. PLoS One. 2016 Oct 6;11(10):e0162532. doi: 10.1371/journal.pone.0162532. PMID:27711210.
Maehana S, Nakamura M, Ogawa F, Imai R, Murakami R, Kojima F, Majima M, Kitasato H. Suppression of lymphangiogenesis by soluble vascular endothelial growth factor receptor-2 in a mouse lung cancer model. Biomed. Pharmacother. 2016 Sep 30;84:660-665. doi: 10.1016/j.biopha.2016.09.083. PMID: 27697638.
Kawashima-Takeda N, Ito Y, Nishizawa N, Kawashima R, Tanaka K, Tsujikawa K, Watanabe M, Majima M. RAMP1 suppresses mucosal injury from dextran sodium sulfate-induced colitis in mice. J. Gastroenterol. Hepatol. 2017 Apr;32(4):809-818. doi:10.1111/jgh.13505. PMID: 27513455.
Kojo K, Ito Y, Eshima K, Nishizawa N, Ohkubo H, Yokomizo T, Shimizu T, Watanabe M, Majima M. BLT1 signalling protects the liver against acetaminophen hepatotoxicity by preventing excessive accumulation of hepatic neutrophils. Sci. Rep. 2016 Jul 11;6:29650. doi: 10.1038/srep29650. PMID: 27404729. PMCID: PMC4939602.
Amano H, Nakamura M, Ito Y, Kakutani H, Eshima K, Kitasato H, Narumiya S, Majima M. Thromboxane A synthase enhances blood flow recovery from hindlimb ischemia. J. Surg. Res. 2016 Jul;204(1):153-63. doi:10.1016/j.jss.2016.04.011. PMID: 27451882.
Okizaki S, Ito Y, Hosono K, Oba K, Ohkubo H, Kojo K, Nishizawa N, Shibuya M, Shichiri M, Majima M. Vascular Endothelial Growth Factor Receptor Type 1 Signaling Prevents Delayed Wound Healing in Diabetes by Attenuating the Production of IL-1β by Recruited Macrophages. Am. J. Pathol. 2016 Jun;186(6):1481-98. doi: 10.1016/j.ajpath.2016.02.014. PMID: 27085138.
Fujita T, Soontrapa K, Ito Y, Iwaisako K, Moniaga CS, Asagiri M, Majima M, Narumiya S. Hepatic stellate cells relay inflammation signaling from sinusoids to parenchyma in mouse models of immune-mediated hepatitis. Hepatology. 2016 Apr;63(4):1325-39. doi: 10.1002/hep.28112. PMID:26248612.
Sekiguchi K, Hosono K, Numao A, Honda M, Matsuda H, Amano H, Kawauchi H, Shibuya M, Unno N, Majima M. Vascular endothelial growth factor regulates growth of endometrial tissues and angiogenesis in a mouse transplantation model. KMJ 2016 Mar;46(1): 15-23.
Park K, Amano H, Ito Y, Kashiwagi S, Yamazaki Y, Takeda A, Shibuya M, Kitasato H, Majima M. Vascular endothelial growth factor receptor-1 (VEGFR-1) signaling enhances angiogenesis in a surgical sponge model. Biomed. Pharmacother. 2016 Mar;78:140-9. doi: 10.1016/j.biopha.2016.01.005. PMID:26898435.
Horikawa S, Ishii Y, Hamashima T, Yamamoto S, Mori H, Fujimori T, Shen J, Inoue R, Nishizono H, Itoh H, Majima M, Abraham D, Miyawaki T, Sasahara M. PDGFRα plays a crucial role in connective tissue remodeling. Sci. Rep. 2015 Dec 7;5:17948. doi: 10.1038/srep17948. PMID: 26639755; PMCID: PMC4671150.
Matsuda H, Hosono K, Tsuru S, Kurashige C, Sekiguchi K, Akira S, Uematsu S, Okamoto H, Majima M. 　Roles of mPGES-1, an inducible prostaglandin E synthase, in enhancement of LPS-induced lymphangiogenesis in a mouse peritonitis model. Life Sci. 2015 Dec 1;142:1-7. doi: 10.1016/j.lfs.2015.10.008. PMID: 26459051.
Amano H, Ito Y, Eshima K, Kato S, Ogawa F, Hosono K, Oba K, Tamaki H, Sakagami H, Shibuya M, Narumiya S, Majima M. Thromboxane A2 induces blood flow recovery via platelet adhesion to ischaemic regions. Cardiovasc. Res. 2015 Sep 1;107(4):509-21. doi: 10.1093/cvr/cvv139. PMID: 25935870.
Amano H, Kato S, Ito Y, Eshima K, Ogawa F, Takahashi R, Sakaguchi K, Tamaki H, Sakagami H, Shibuya M, Majima M. The roles of vascular endothelial growth factor receptor 1 signaling in recovery from ischemia. PLoS One. 2015 Jul 2;10(7):e0131445. doi: 10.1371/journal.pone.0131445.
Matsui Y, Amano H, Ito Y, Eshima K, Tamaki H, Ogawa F, Iyoda A, Shibuya M, Kumagai Y, Satoh Y, Majima M.  The role of vascular endothelial growth factor receptor-1 signaling in compensatory contralateral lung growth following unilateral pneumonectomy. Lab. Invest. 2015 May;95(5):456-68. doi: 10.1038/labinvest.2014.159. PMID: 25642830.
Minamino T, Ito Y, Ohkubo H, Shimuzu Y, Kojo K, Nishizwa N, Amano H, Narumiya S, Koizumi W, Majima M. Adhesion of platelets through thromboxane A₂ receptor signaling facilitates liver repair during acute chemical-induced hepatotoxicity. Life Sci. 2015 Jul 1;132:85-92. doi: 10.1016/j.lfs.2015.03.015.
Sato C, Kamijo Y, Yoshimura K Inagaki T, Yamaya T, Asakuma S, Majima M, Asari Y. Effects of hydrogen water on paraquat-induced pulmonary fibrosis in mice. KMJ 2015 Mar;45(1): 9-16.
Ogawa F, Amano H, Eshima Y, Ito Y, Matsui Y, Hosono K, Kitasato H, Iyoda A, Iwabuchi K, Kumagai Y, Satoh Y, Narumiiya S, Majima M. Prostanoid induces premetastatic niche in regional lymph nodes. J. Clin. Invest. 2014 Nov;124(11):4882-94. doi: 10.1172/JCI73530. PMID: 25271626.
Amano H., Ito Y., Eshima K., Kato S., Ogawa F., Hosono K., Oba K., Tamaki H., Sakagami H., Shibuya M., Narumiya S., Majima M.  ThromboxaneA2 induces blood flow recovery via platelet adhesion to ischemic regions.  Cardiovascular Res. 2015 Sep 1;107(4):509-21. doi: 10.1093/cvr/cvv139.
H. Amano, S. Kato, Y. Ito, R. Takahashi, K. Eshima, K Sakaguchi, H. Tamaki, H. Sakagami, F. Ogawa, M. Shibuya, M. Majima. Roles of vascular endothelial growth factor receptor 1 signaling in recovery from ischemia. PLoS One 2015 Jul 2;10(7):e0131445.
Minamino T. Ito Y. Ohkubo H. Shimizu Y. Kojo K. Nishizawa N. Amano H. Narumiya S. Koizumi W, Majima M.  Adhesion of platelets through thromboxane A2 receptor signaling facilitates liver repair during acute chemical-induced hepatotoxicity.  Life Sciences. 2015 Jul 1;132:85-92. doi: 10.1016/j.lfs.2015.03.015. PMID: 25921763.
Matsui Y, Amano H, Ito Y, Eshima K, Tamaki H, Ogawa F, Iyoda A, Shibuya M, Kumagai Y, Satoh Y, Majima M.  The role of vascular endothelial growth factor receptor-1 signaling in compensatory contralateral lung growth following unilateral pneumonectomy.  Laboratory Investigation. 2015 May;95(5):456-68. doi: 10.1038/labinvest.2014.159. PMID: 25642830.
Okizaki S, Ito Y, Hosono K, Oba K, Ohkubo H, Amano H, Shichiri M, Majima M. Suppressed recruitment of alternatively activated macrophages reduces TGF-β1 and impairs wound healing in streptozotocin-induced diabetic mice. Biomed. Pharmacother. 2015 Mar;70:317-25. doi: 10.1016/j.biopha.2014.10.020. PMID:25677561.
Majima M. Roles of prostaglandins in regulation of pathological angiogenesis and lymphangiogenesis. Bioactive Lipid Mediators 2015; 18:253-266.
Kamata M, Hosono K, Fujita T, Kamata K, Majima M.  Role of cyclooxygenase-2 in the development of interstitial fibrosis in kidneys following unilateral ureteral obstruction in mice. Biomed. Pharmacother. 2015 Mar;70:174-80. doi: 10.1016/j.biopha.2015.01.010. PMID: 25776498.
Ogawa F, Satoh Y, Iyoda A, Amano H, Kumagai Y, Majima M.  Clinical impact of lung age on postoperative readmission in non-small cell.  J. Surg. Res. 2015 Jan;193(1):442-8. doi: 10.1016/j.jss.2014.08.028. PMID: 25255723.
Ogawa F, Amano H, Eshima Y, Ito Y, Matsui Y, Hosono K, Kitasato H, Iyoda A, Iwabuchi K, Kumagai Y, Satoh Y, Narumiiya S, Majima M. Prostanoid induces premetastatic niche in regional lymph nodes.   J. Clin. Invest. 2014 Nov 3;124(11):4882-94. doi: 10.1172/JCI73530. PMID: 25271626.
Oba K, Hosono K, Amano H, Okizaki S, Ito Y, Shichiri M, Majima M.  Downregulation of the proangiogenic prostaglandin E receptor EP3 and reduced angiogenesis in a mouse model of diabetes mellitus. Biomed. Pharmacother. 2014 Oct;68(8):1125-33. doi: 10.1016/j.biopha.2014.10.022. PMID: 25465154.
Katori M, Majima M. Renal (tissue) kallikrein-kinin system in the kidney and novel potential drugs for salt-sensitive hypertension. Prog. Drug Res. 2014; 69: 59-109. PMID: 25130040.
Ohkubo H, Ito Y, Minamino T, Eshima K, Kojo K, Okizaki S, Hirata M, Shibuya M, Watanabe M, Majima M.  VEGFR1-positive macrophages facilitate liver repair and sinusoidal reconstruction after hepatic ischemia/reperfusion injury. PLoS One 2014 Aug 27;9(8):e105533. doi: 10.1371/journal.pone.0105533. eCollection 2014. PMID: 25162491.
Kurashige C, Hosono K, Matsuda H, Tsujikawa K, Okamoto H, Majima M. Roles of receptor activity-modifying protein 1 in angiogenesis and lymphangiogenesis during skin wound healing in mice. FASEB J. 2014 Mar;28(3):1237-47. doi: 10.1096/fj.13-238998. PMID: 24308973.
Sato T, Amano H, Ito Y, Eshima K, Minamino T, Ae T, Katada C, Ohno T, Hosono K, Suzuki T, Shibuya M, Koizumi W, Majima M. Vascular endothelial growth factor receptor 1 signaling facilitates gastric ulcer healing and angiogenesis through the up regulation of epidermal growth factor expression on VEGFR1+ CXCR4+ cells recruited from bone marrow. J. Gastroenterol. 2014 Mar;49(3):455-69. doi: 10.1007/s00535-013-0869-z. PMID: 23982810.
Takahashi R, Amano H, Satoh T, Tabata K, Ikeda M, Kitasato H, Akira S, Iwamura M, Majima M. Roles of microsomal prostaglandin E synthase-1 in lung metastasis formation in prostate cancer RM9 cells. Biomed. Pharmacother. 2014 Feb;68(1):71-7. doi: 10.1016/j.biopha.2013.10.008. PMID: 24291175.
Ogawa F, Amano H, Ito H, Matsui Y, Hosono K, Kitasato H, Satoh Y, Majima M. Aspirin reduces lung cancer metastasis to regional lymph nodes. Biomed. Pharmacother. 2014 Feb;68(1):79-86. doi: 10.1016/j.biopha.2013.11.006. PMID: 24331369.
Fujita T, Yasuda S, Kamata T, Kamata K, Kumagai Y, Majima M. A common polymorphism in the tissue kallikrein gene is associated with increased urinary excretions of calcium and sodium in Japanese volunteers. J. Hum. Genet.2013 Nov;58(11):758-61. doi: 10.1038/jhg.2013.93. doi: 10.1038/jhg.2013.93. PMID: 24005896.
Sato T, Amano H, Ito Y, Eshima K, Minamino T, Ae T, Katada C, Ohno T, Hosono K, Suzuki T, Shibuya M, Koizumi W, Majima M. NSAID, aspirin delays gastric ulcer healing with reduced accumulation of CXCR4+ VEGFR1+ cells to the ulcer granulation tissues.  Biomed. Pharmacother. 2013 Sep;67(7):607-613. doi: 10.1016/j.biopha.2013.01.009. PMID: 23809370.
Ohkubo H, Ito Y, Minamino T, Mishima T, Hirata M, Hosono K, Shibuya M, Yokomizo T, Shimizu T, Watanabe M, Majima M.  Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment. FASEB J. 2013 Aug;27(8):3132-43. doi: 10.1096/fj.13-227421. PMID: 23629862.
Sato T, Amano H, Ito Y, Eshima K, Minamino T, Ae T, Katada C, Ohno T, Hosono K, Suzuki T, Shibuya M, Koizumi W, Majima M. Aspirin delays the healing of acetic acid-induced gastric ulcer with attenuated recruitment of hematopoietic progenitor cells to ulcer granulation tissue in mice. KMJ 2013 Mar;43(1): 57-66.
Amano H, Ito Y, Ogawa F, Eshima K, Suzuki T, Oba K, Matsui Y, Kato S, Fukui T, Nakamura M, Kitasato H, Fukamizu A, Majima M. Angiotensin II type 1a signaling facilitates tumor metastasis formation through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells. Am. J. Pathol. 2013 Feb;182(2):553-64. doi: 10.1016/j.ajpath.2012.10.026. PMID: 23219751.
Nakamura M, Tsumura H, Satoh T, Matsumoto K, Maruyama H, Majima M, Kitasato H.  Tumor apoptosis in prostate cancer by PGD2 and its metabolite 15d-PGJ2 in murine model.  Biomed. Pharmacother.2013 Feb;67(1):66-71. doi: 10.1016/j.biopha.2012.10.012. PMID: 23206752.
Kato T, Ito Y, Majima M. VEGF/VEGFR signaling in the liver repair from acetaminophen hepatotoxicity. Inflammation and Regeneration. 2013 Jan; 33(1):66-71.
Fujita T, Ishihara K, Yasuda S, Nakamura T, Maeda M, Kobayashi M, Sahashi K, Ikeda Y, Kumagai Y, Majima M.  In vivo kinetics of indoxyl sulfate in humans and its renal interaction with angiotensin-converting enzyme inhibitor quinapril in rats. J. Pharmacol. Exp. Ther. 2012 Jun;341(3):626-33. doi:10.1124/jpet.111.187732. PMID: 22389425.
Matsui Y, Amano H, Ito Y, Eshima K, Suzuki T, Ogawa F, Iyoda A, Satoh Y, Kato S, Nakamura M, Kitasato H, Narumiya S, Majima M.  Thromboxane A2 receptor signaling facilitates tumor colonization through P-selectin mediated interaction of platelets with tumor cells and endothelial cells.  Cancer Sci. 2012 Apr;103(4):700-7. doi: 10.1111/j.1349-7006.2012.02200.x. PMID: 22296266.
Matsui Y, Amano H, Ito Y, Eshima K, Kato S, Ogawa F, Iyoda A, Narumiya S, Satoh Y, Majima M. Role of thromboxane A2 in enhancement of lung metastasis through the increased adhesion of platelets to tumor cells in mice. KMJ 2012 Mar;42(1): 39-50.
Minamino T, Ito Y, Ohkubo H, Hosono K, Suzuki T, Sato T, Ae T, Shibuya A, Sakagami H, Narumiya S, Koizumi W, Majima M. Thromboxane A(2) receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment. Toxicol. Appl. Pharmacol. 2012 Feb 15;259(1):104-14. doi: 10.1016/j.taap.2011.12.013. PMID: 22206755.
Kashiwagi S, Hosono K, Suzuki T, Takeda A, Uchinuma E, Majima M. Role of COX-2 in lymphangiogenesis and restoration of lymphatic flow in secondary lymphedema. Lab. Invest. 2011 Sep;91(9):1314-25. doi: 10.1038/labinvest.2011.84. PMID: 21577211.
Katoh H, Hosono K, Suzuki T, Watanabe M, Majima M. EP3/EP4 signaling regulates tumor microenvironment formation by bone marrow-derived fibroblasts. Inflammation and Regeneration 2011 Jun;31(3): 316-324.
Hosono K, Suzuki T, Tamaki H, Sakagami H, Hayashi I, Narumiya S, Alitalo K, Majima M. Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation. Arterioscler. Thromb. Vasc. Biol. 2011 May;31(5):1049-58. doi: 10.1161/ATVBAHA.110.222356. PMID: 21311040.
Katoh H, Hosono K, Suzuki T, Watanabe M, Majima M.  EP3/EP4 signaling regulates tumor microenvironment formation by bone marrow-derived fibroblasts. Inflammation and Regeneration.2011 May;31(3):316-324.
Isono M, Suzuki T, Hosono K, Hayashi I, Sakagami H, Uematsu S, Akira S, DeClerck YA, Okamoto H, Majima M. Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice. Life Sci. 2011 Apr 11;88(15-16):693-700. doi: 10.1016/j.lfs.2011.02.008. PMID: 21324324.
Majima M, Toda M, Ito Y, Ohno T, Mishima T, Suzuki T, Hosono K, Hayashi I. Roles of calcitonin gene-related peptide in ehancement of angiogenesis. Inflammation and Regeneration 2011 March;31(2): 146-150.
Nakamura M, Yamaguchi S, Motoyoshi K, Negishi M, Saiti-Taki T, Matsumoto K, Hayashi I, Majima M, Kitasato H.  Anti-tumor effects of prostaglandin D2 and its metabolites, 15-deoxy-Δ12, 14-PGJ2, by peroxisome proliferator-activated receptor (PPAR)γ-dependent and -independent pathways. Inflammation and Regeneration.2011 March;31(2):189-195.
Nagashima Y, Igaki M, Suzuki A, Tsuchiya S, Yamazaki Y, Hishinuma M, Oh-Ishi S, Majima M. Application of a heat- and steam-generating sheet increases peripheral blood flow and induces parasympathetic predominance. Evid. Based Complement Alternat. Med. 2011;2011:965095. doi: 10.1155/2011/965095.PMID: 21584198.PMCID: PMC3092738.
Kato T, Ito Y, Hosono K, Suzuki T, Tamaki H, Minamino T, Kato S, Sakagami H, Shibuya M, Majima M. Vascular endothelial growth factor receptor-1 signaling promotes liver repair through restoration of liver microvasculature after acetaminophen hepatotoxicity. Toxicol. Sci. 2011 Mar;120(1):218-29. doi: 10.1093/toxsci/kfq366. PMID: 21135413.
Kamata H, Hosono K, Suzuki T, Ogawa Y, Kubo H, Katoh H, Ito Y, Uematsu S, Akira S, Watanabe M, Majima M. Roles of an inducible prostaglandin E synthase, mPGES-1 in host in enhancement of tumor-associated angiogenesis. KMJ 2011 Mar;41(1): 19-30.
Numao A, Hosono K, Suzuki T, Hayashi I, Uematsu S, Akira S, Ogino Y, Kawauchi H, Unno N, Majima M. The inducible prostaglandin E synthase mPGES-1 regulates growth of endometrial tissues and angiogenesis in a mouse implantation model. Biomed. Pharmacother. 2011 Feb;65(1):77-84. doi: 10.1016/j.biopha.2010.12.008. PMID: 21247731.
Mishima T, Ito Y, Hosono K, Tamura Y, Uchida Y, Hirata M, Suzsuki T, Amano H, Kato S, Kurihara Y, Kurihara H, Hayashi I, Watanabe M, Majima M. Calcitonin gene-related peptide facilitates revascularization during hindlimb ischemia in mice. Am. J. Physiol. Heart Circ. Physiol. 2011 Feb;300(2):H431-9. doi: 10.1152/ajpheart.00466.PMID: 21131474.
Ae T, Ohno T, Hattori Y, Suzuki T, Hosono K, Minamino T, Sato T, Uematsu S, Akira S, Koizumi W, Majima M. Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers. Am. J. Physiol. Gastrointest. Liver Physiol. 2010 Nov;299(5):G1139-46. doi: 10.1152/ajpgi.00013. PMID: 20813913.
Mizuguchi S, Ohno T, Hattori Y, Ae T, Minamino T, Satoh T, Arai K, Saeki T, Hayashi I, Sugimoto Y, Narumiya S, Saigenji K, Majima M. Roles of prostaglandin E2-EP1 receptor signaling in regulation of gastric motor activity and emptying. Am. J. Physiol. Gastrointest. Liver Physiol. 2010 Nov;299(5):G1078-86. doi: 10.1152/ajpgi.00524.2009. PMID: 20798358.
Kosaka Y, Suzuki T, Hosono K, Okazaki H, Yokomizo T, Shimizu T, Hayashi I, Okamoto H, Majima M. Roles of BLT1 signaling in enhancement of angiogenesis during development of chronic inflammation. KMJ 2010 Sep;40(2): 135-143.
Kamata H, Hosono K, Suzuki T, Ogawa Y, Kubo H, Katoh H, Ito Y, Uematsu S, Akira S, Watanabe M, Majima M. mPGES-1-expressing bone marrow-derived cells enhance tumor growth and angiogenesis in mice. Biomed. Pharmacother. 2010 Jul;64(6):409-16. doi: 10.1016/j.biopha.2010.01.017.PMID: 20452172.
Katoh H, Hosono K, Ito Y, Suzuki T, Ogawa Y, Kubo H, Kamata H, Mishima T, Tamaki H, Sakagami H, Sugimoto Y, Narumiya S, Watanabe M, Majima M. COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems. Am. J. Pathol. 2010 Mar;176(3):1469-83. doi: 10.2353/ajpath.2010.090607. PMID: 20110411.
Kato S, Amano H, Ito Y, Eshima K, Aoyama N, Tamaki H, Sakagami H, Satoh Y, Izumi T, Majima M. Effect of erythropoietin on angiogenesis with the increased adhesion of platelets to the microvessels in the hind-limb ischemia model in mice. J. Pharmacol. Sci. 2010 Feb;112(2):167-75. PMID: 20134117.
Kubo H, Hosono K, Suzuki T, Ogawa Y, Kato H, Kamata H, Ito Y, Amano H, Kato T, Sakagami H, Hayashi I, Sugimoto Y, Narumiya S, Watanabe M, Majima M. Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis. Biomed. Pharmacother. 2010 Feb;64(2):101-6. doi: 10.1016/j.biopha.2009.04.039.PMID: 20034758.
Ueno T, Suzuki T, Oikawa A, Hosono K, Kosaka Y, Amano H, Kitasato H, Toda M, Hayashi I, Kato T, Ito Y, Sugimoto Y, Narumiya S, Okamoto H, Majima M. Recruited bone marrow cells expressing the EP3 prostaglandin E receptor subtype enhance angiogenesis during chronic inflammation. Biomed. Pharmacother. 2010 Feb;64(2):93-100. doi: 10.1016/j.biopha.2009.04.034. PMID: 20015609.
Fujita T, Kumagai Y, Nakahara I, Ohtani Y, Majima M. Estimating the contribution of genes to variation in renal drug clearance by active secretion using multiple data from clinical phase I studies. J. Clin. Pharmacol. 2010 Jan;50(1):109-14. doi: 10.1177/0091270009348502. PMID: 19897765.
Kamei D, Murakami M, Sasaki Y, Nakatani Y, Majima M, Ishikawa Y, Ishii T, Uematsu S, Akira S, Hara S, Kudo I. Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis. Biochem. J. 2009 Dec 23;425(2):361-71. doi: 10.1042/BJ20090045.PMID: 19845504.
Amano H, Ohnuma Y, Niibe Y, Hayakawa K, Satoh Y, Majima M. Combined effect of anti-angiogenic agents, angiotensin type 1 receptor antagonists and radiation therapy. Current Signal Transduction Therapy 2010; 5:206-211.
Katori M, Majima M. A proposal---The renal kallikrein-kinin system as a compensating system for salt accumulation after excess salt intake. Current Hypertension Reviews 210; 6:238-250.
Amano H, Ito Y, Suzuki T, Kato S, Matsui Y, Ogawa F, Murata T, Sugimoto Y, Senior R, Kitasato H, Hayashi I, Satoh Y, Narumiya S, Majima M. Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis. Cancer Sci. 2009 Dec;100(12):2318-24. doi:10.1111/j.1349-7006.2009.01322.x. PMID: 19799610.
Kurosaka M, Suzuki T, Hosono K, Kamata Y, Fukamizu A, Kitasato H, Fujita Y, Majima M. Reduced angiogenesis and delay in wound healing in angiotensin II type 1a receptor-deficient mice. Biomed. Pharmacother. 2009 Nov;63(9):627-34. doi: 10.1016/j.biopha.2009.01.001. PMID: 19464844.
Ogawa Y, Suzuki T, Oikawa A, Hosono K, Kubo H, Amano H, Ito Y, Kitasato H, Hayashi I, Kato T, Sugimoto Y, Narumiya S, Watanabe M, Majima M. Bone marrow-derived EP3-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth. Biochem. Biophys. Res. Commun. 2009 May 15;382(4):720-5. doi: 10.1016/j.bbrc.2009.03.094.PMID: 19318087.
Nakatani K, Koizumi W, Suzuki T, Hosono K, Higuchi K, Tanabe S, Kitasato H, Saigenji K, Majima M. Roles of AT2 receptor signaling in ascites accumulation and intraperitoneal bleeding in a mouse peritoneal carcinomatosis model. The KMJ 2009 Mar;39(1): 91-101.
Kamata Y, Fujita T, Kato T, Hayashi I, Kurosaka M, Katori M, Fujita Y, Majima M. An ATP-sensitive potassium channel blocker suppresses sodium-induced hypertension through increased secretion of urinary kallikrein. Hypertens. Res. 2009 Mar;32(3):220-6. doi: 10.1038/hr.2008.33.PMID: 19262486.
Ohnuma Y, Toda M, Fujita M, Hosono K, Suzuki T, Ogawa Y, Amano H, Kitasato H, Hayakawa K, Majima M. Blockade of an angiotensin type I receptor enhances effects of radiation on tumor growth and tumor-associated angiogenesis by reducing vascular endothelial growth factor expression. Biomed. Pharmacother. 2009 Feb;63(2):136-45. doi: 10.1016/j.biopha.2007.11.005.PMID: 18691848.
Kamijo Y, Hayashi I, Ide A, Yoshimura K, Soma K, Majima M. Effects of inhaled monoethanolamine on bronchoconstriction. J. Appl. Toxicol. 2009 Jan;29(1):15-9. doi: 10.1002/jat.1373. PMID: 18651722.
Fujita T, Yasuda S, Kamata Y, Fujita K, Ohtani Y, Kumagai Y, Majima M. Contribution of down regulation of intestinal and hepatic cytochrome P450 3A to increased absorption of cyclosporine A in a rat nephrosis model. J. Pharmacol. Exp. Ther. 2008 Nov;327(2):592-9. doi: 10.1124/jpet.108.142091. PMID: 18725544.
Katagiri H, Ito Y, Ito S, Murata T, Yukihiko S, Narumiya S, Watanabe M, Majima M. TNF-alpha induces thromboxane receptor signaling-dependent microcirculatory dysfunction in mouse liver. Shock. 2008 Oct;30(4):463-7. doi: 10.1097/shk.0b013e3181673f54.
Katori M, Majima M. Are all individuals equally sensitive in the blood pressure to high salt intake? Acta. Physiol. Hung. 2008 Sep;95(3):247-65. doi: 10.1556/APhysiol.95.2008.3.2. PMID: 18788465.
Toda M, Suzuki T, Hosono K, Hayashi I, Hashiba S, Onuma Y, Amano H, Kurihara Y, Kurihara H, Okamoto H, Hoka S, Majima M. Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide. Proc. Natl. Acad. Sci. U S A. 2008 Sep 9;105(36):13550-5. doi: 10.1073/pnas.0800767105.PMID: 18757746.
Toda M, Suzuki T, Hosono K, Kurihara Y, Kurihara H, Hayashi I, Kitasato H, Hoka S, Majima M. Roles of calcitonin gene-related peptide in facilitation of wound healing and angiogenesis. Biomed. Pharmacother. 2008 Jul-Aug;62(6):352-9. doi: 10.1016/j.biopha.2008.02.003.PMID: 18430544.
Ito S, Ito Y, Katagiri H, Suzuki T, Hoka S, Yokomizo T, Shimizu T, Majima M. Leukotriene B4/leukotriene B4 receptor pathway is involved in hepatic microcirculatory dysfunction elicited by endotoxin. Shock. 2008 Jul;30(1):87-91. doi: 10.1097/shk.0b013e31815d06a1. PMID: 18004232.
Ide A, Kamijo Y, Yoshimura K, Soma K, Majima M. Mechanism of bronchoconstriction induced by inhaled cresol. KMJ 2008 Mar;38(1): 24-28.
Katori M, Majima M. A role of the renal kallikrein-kinin system in the kidney. Acta. Physiol. Hung. 2008 Mar;95(1):127-8. doi: 10.1556/APhysiol.95.2008.1.10. PMID: 18390005.
Yang SJ, Katori M, Majima M. A novel model of pain sensation using superfused gastrosplenic omentum preparation of anesthetized rats. J. Pharmacol. Sci. 2008 Feb;106(2):249-56. PMID: 18270472.
Hattori Y, Ohno T, Ae T, Saeki T, Arai K, Mizuguchi S, Saigenji K, Majima M. Gastric mucosal protection against ethanol by EP2 and EP4 signaling through the inhibition of leukotriene C4 production. Am. J. Physiol. Gastrointest. Liver Physiol. 2008 Jan;294(1):G80-7. doi: 10.1152/ajpgi.00292.2007. PMID: 1794753.
Ohno T, Hattori Y, Komine R, Ae T, Mizuguchi S, Arai K, Saeki T, Suzuki T, Hosono K, Hayashi I, Oh-Hashi Y, Kurihara Y, Kurihara H, Amagase K, Okabe S, Saigenji K, Majima M. Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis. Gastroenterology. 2008 Jan;134(1):215-25. doi: 10.1053/j.gastro.2007.10.001. PMID: 18054007.
Fujita T, Nakamura K, Yamazaki A, Ozaki M, Sahashi K, Shichijo K, Nomura K, Maeda M, Nakamura T, Fujita T, Yokota S, Kuroyama S, Kumagai Y, Majima M, Ohtani Y. Effect of L-phenylalanine supplementation and a high-protein diet on pharmacokinetics of cefdinir in healthy volunteers: an exploratory study. J. Clin. Pharm. Ther. 2007 Jun;32(3):277-85. doi: 10.1111/j/1365-2710/2007.00826.x. PMID: 1789880.
Akira Yamazaki, Yuji Kumagai, Tomoe Fujita, Tomoko Hasunuma, Shinichi Yokota, Mika Maeda, Masataka Majima. Roles of AT2 receptor signaling in ascites accumulation and intraperitoneal bleeding in a mouse peritoneal carcinomatosis model. KMJ 2007 Mar;37(1):22-27.
Yamazaki A, Kumagai Y, Fujita T, Hasunuma T, Yokota S, Maeda M, Otani Y, Majima M. Different effects of light food on pharmacokinetics and pharmacodynamics of three benzodiazepines, quazepam, nitrazepam and diazepam. J. Clin. Pharm. Ther. 2007 Feb;32(1):31-9. doi: 10.1111/j.1365-2710.2007.00795.x. PMID: 17286787.
Kamoshita E, Ikeda Y, Fujita M, Amano H, Oikawa A, Suzuki T, Ogawa Y, Yamashina S, Azuma S, Narumiya S, Unno N, Majima M. Recruitment of a prostaglandin E receptor subtype, EP3-expressing bone marrow cells is crucial in wound-induced angiogenesis. Am. J. Pathol. 2006 Oct;169(4):1458-72. doi: 10.2353/ajpath.2006.051358. PMID: 17003499.
Fujita T, Ogino M, Daigo F, Yamaguchi T, Majima M. Intracellular Ca2+ contributes to K+-induced increase in renal kallikrein secretion. Int. Immunopharmacol. 2006 Sep;6(9):1487-95. doi: 10.1016/j.intimp.2006.05.003. PMID: 16846843.
Fujita T, Matsumoto Y, Ozaki M, Majima M, Kumagai Y, Ohtani Y. Comparison of maximum drug concentration and area under the time-concentration curve between humans and animals for oral and intravenous investigational drugs. J. Clin. Pharmacol. 2006 Jun;46(6):674-92. doi: 10.1177/0091270006287932. PMID: 16707414.
Katori M, Majima M. A missing link between a high salt intake and blood pressure increase. J. Pharmacol. Sci. 2006 Jun;100(5):370-90. PMID: 16651701.
Fujita T, Yokota S, Sawada M, Majima M, Ohtani Y, Kumagai Y. Effect of MKC-733, a 5-HT receptor partial agonist, on bowel motility and symptoms in subjects with constipation: an exploratory study. J. Clin. Pharm. Ther. 2005 Dec;30(6):611-22. doi: 10.1111/j.1365-2710.2005.00695.x. PMID: 16336295.
Matsumoto Y, Fujita T, Ishida Y, Shimizu M, Kakuo H, Yamashita K, Majima M, Kumagai Y. Population pharmacokinetic-pharmacodynamic modeling of TF-505 using extension of indirect response model by incorporating a circadian rhythm in healthy volunteers. Biol. Pharm. Bull. 2005 Aug;28(8):1455-61. PMID: 16079492.
Motohashi E, Kawauchi H, Endo H, Kondo H, Kitasato H, Kuramoto H, Majima M, Unno N, Hayashi I. Regulatory expression of lipoxin A4 receptor in physiologically estrus cycle and pathologically endometriosis. Biomed. Pharmacother. 2005 Jul;59(6):330-8. doi: 10.1016/j.biopha.2005.05.005. PMID: 15996849.
Mizuguchi S, Ohno T, Hattori Y, Kamata K, Arai K, Saeki T, Saigenji K, Hayashi I, Kuribayashi Y, Majima M. Calcitonin gene-related peptide released by capsaicin suppresses myoelectrical activity of gastric smooth muscle. J. Gastroenterol. Hepatol. 2005 Apr;20(4):611-8. doi: 10.1111/j.1440-1746.2004.03764.x. PMID: 15836712.
Fujita T, Majima M. Gene structure, biosynthesis and function of kininogen. JPS 2005 Mar;63 Suppl 3:357-62. PMID: 15813094.
Fujita M, Hayashi I, Yamashina S, Fukamizu A, Itoman M, Majima M. Angiotensin type 1a receptor signaling-dependent induction of vascular endothelial growth factor in stroma is relevant to tumor-associated angiogenesis and tumor growth. Carcinogenesis. 2005 Feb;26(2):271-9. doi: 10.1093/carcin/bgh324. PMID: 15637093.
Amano H, Hayashi I, Yoshimura H, Majima M. Prostanoid receptor in tumor-associated angiogenesis and tumor growth. Inflammation and Regeneration 2005 Jan;25(1): 26-31.
Katori M, Majima M. Roles of the renal kallikrein-kinin system in salt-sensitive hypertension. Hypertension. 2004 Dec;44(6):e12. Epub 2004 Oct 18. doi: 10.1161/01.HYP.0000146401.40304.51. PMID: 15492137.
Kobayashi T, Tahara Y, Matsumoto M, Iguchi M, Sano H, Murayama T, Arai H,Oida H, Yurugi-Kobayashi T, Yamashita JK, Katagiri H, Majima M, Yokode M, Kita T, Narumiya S. Roles of thromboxane A(2) and prostacyclin in the development of atherosclerosis in apoE-deficient mice. J. Clin. Invest. 2004 Sep;114(6):784-94. doi: 10.1172/JCI21446. PMID: 15372102.
Ikeda Y, Hayashi I, Kamoshita E, Yamazaki A, Endo H, Ishihara K, Yamashina S, Tsutsumi Y, Matsubara H, Majima M. Host stromal bradykinin B2 receptor signaling facilitates tumor-associated angiogenesis and tumor growth. Cancer Res. 2004 Aug 1;64(15):5178-85. doi: 10.1158/0008-5472.CAN-03-3589. PMID: 15289322.
Igawa S, Hayashi I, Tanaka N, Hiruma H, Majima M, Kawakami T, Hirose M, Masuda N, Kobayashi H. Nitric oxide generated by iNOS reduces deformability of Lewis lung carcinoma cells. Cancer Sci. 2004 Apr;95(4):342-7. PMID: 15072593.
Katagiri H, Ito Y, Ishii K, Hayashi I, Suematsu M, Yamashina S, Murata T, Narumiya S, Kakita A, Majima M. Role of thromboxane derived from COX-1 and -2 in hepatic microcirculatory dysfunction during endotoxemia in mice. Hepatology. 2004 Jan;39(1):139-50. doi: 10.1002/hep.20000. PMID: 14752832.
Saeki T, Ohno T, Kamata K, Arai K, Mizuguchi S, Katori M, Saigenji K, Majima M. Mild irritant prevents ethanol-induced gastric mucosal microcirculatory disturbances through actions of calcitonin gene-related peptide and PGI2 in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 2004 Jan;286(1):G68-75. doi: 10.1152/ajpgi.00538.2002. PMID: 14665438.
Yoshida S, Amano H, Hayashi I, Kitasato H, Kamata M, Inukai M, Yoshimura H, Majima M. COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo. Lab. Invest. 2003 Oct;83(10):1385-94.PMID: 14563940.
Majima M, Amano H, Hayashi I. Prostanoid receptor signaling relevant to tumor growth and angiogenesis. Trends Pharmacol. Sci. 2003 Oct;24(10):524-9. Review. doi: 10.1016/j.tips.2003.08.005. PMID: 14559404.
Ito Y, Katagiri H, Ishii K, Kakita A, Hayashi I, Majima M. Effects of selective cyclooxygenase inhibitors on ischemia/reperfusion-induced hepatic microcirculatory dysfunction in mice. Eur. Surg. Res. 2003 Sep-Oct;35(5):408-16. doi: 10.1159/000072174. PMID: 12928598.
Arai K, Ohno T, Saeki T, Mizuguchi S, Kamata K, Hayashi I, Saigenji K, Murata T, Narumiya S, Majima M. Endogenous prostaglandin I2 regulates the neural emergency system through release of calcitonin gene related peptide. Gut. 2003 Sep;52(9):1242-9. PMID: 12912853. PMCID: PMC1773782.
Takada T, Matsubara M, Okumura T, Saigenji K, Majima M, Hayashi I, Furudate S, Oh-Ishi M, Kodera Y, Maeda T, Fujita Y. Hyperglycemia-induced Alteration in Proteomes of the Rat Renal Cortex. KMJ 2003 Aug;33(4): 223-232.
Ando M, Murakami Y, Kojima F, Endo H, Kitasato H, Hashimoto A, Kobayashi H, Majima M, Inoue M, Kondo H, Kawai S, Hayashi I. Retrovirally introduced prostaglandin D2 synthase suppresses lung injury induced by bleomycin. Am. J. Respir. Cell Mol. Biol. 2003 May;28(5):582-91. doi:10.1165/rcmb.2002-0162OC. PMID: 12707014.
Yamaguchi-Sase S, Hayashi I, Okamoto H, Nara Y, Matsuzaki S, Hoka S, Majima M. Amelioration of hyperalgesia by kinin receptor antagonists or kininogen deficiency in chronic constriction nerve injury in rats. Inflamm. Res. 2003 Apr;52(4):164-9. PMID: 12755382.
Katori M, Majima M. The renal kallikrein-kinin system: its role as a safety valve for excess sodium intake, and its attenuation as a possible etiologic factor in salt-sensitive hypertension. Crit. Rev. Clin. Lab. Sci. 2003 Feb;40(1):43-115. doi: 10.1080/713609329. PMID: 12627748.
Amano H, Hayashi I, Endo H, Kitasato H, Yamashina S, Maruyama T, Kobayashi M, Satoh K, Narita M, Sugimoto Y, Murata T, Yoshimura H, Narumiya S, Majima M. Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. J. Exp. Med. 2003 Jan 20;197(2):221-32. PMID: 12538661. PMCID: PMC2193807.
Ito H, Hayashi I, Izumi T, Majima M. Bradykinin inhibits development of myocardial infarction through B2 receptor signalling by increment of regional blood flow around the ischaemic lesions in rats. Br. J. Pharmacol. 2003 Jan;138(1):225-33. doi: 10.1038/sj.bjp.0705013. PMID: 12522094. PMCID: PMC1573639.
Matsuzaki S, Hayashi I, Nara Y, Kamata K, Yamanaka M, Okamoto H, Hoka S, Majima M. Role of kinin and prostaglandin in cutaneous thermal nociception. Int. Immunopharmacol. 2002 Dec;2(13-14):2005-12. PMID: 12489814.
Yamanaka M, Hayashi I, Fujita T, Cha SH, Endou H, Higashihara M, Majima M. Potassium-induced increase in renal kallikrein secretion is attenuated in dissected renal connecting tubules of young spontaneously hypertensive rats. Int. Immunopharmacol. 2002 Dec;2(13-14):1957-64. PMID: 12489809.
Sakamoto I, Takahashi T, Kakita A, Hayashi I, Majima M, Yamashina S. Experimental study on hepatic reinnervation after orthotopic liver transplantation in rats. J. Hepatol. 2002 Dec;37(6):814-23. PMID: 12445423.
Okumura T, Hayashi I, Ikezawa T, Yamanaka M, Takata T, Fujita Y, Saigenji K, Yamashina S, Majima M. Cyclooxygenase-2 inhibitors attenuate increased blood pressure in renovascular hypertensive models, but not in deoxycorticosterone-salt hypertension. Hypertens. Res. 2002 Nov;25(6):927-38. PMID: 12484518.
Kamata K, Hayashi I, Mizuguchi Y, Arai K, Saeki T, Ohno T, Saigenji K, Majima M. Suppression of dextran sulfate sodium-induced colitis in kininogen-deficient rats and non-peptide B2 receptor antagonist-treated rats. Jpn. J. Pharmacol. 2002 Sep;90(1):59-66. PMID: 12396028.
Fujita T, Matsumoto Y, Kimura T, Yokota S, Sawada M, Majima M, Ohtani Y, Kumagai Y. Pharmacokinetics and pharmacodynamics of TF-505, a novel nonsteroidal 5alpha-reductase inhibitor, in normal subjects treated with single or multiple doses. Br. J. Clin. Pharmacol. 2002 Sep;54(3):283-94.
Katada J, Muramatsu M, Hayashi I, Tsutsumi M, Konishi Y, Majima M. Significance of vascular endothelial cell growth factor up-regulation mediated via a chymase-angiotensin-dependent pathway during angiogenesis in hamster sponge granulomas. J. Pharmacol. Exp. Ther. 2002 Sep;302(3):949-56. doi: 10.1124/jpet.102.034231. PMID: 12183651.
Ishii K, Ito Y, Katagiri H, Matsumoto Y, Kakita A, Majima M. Neutrophil elastase inhibitor attenuates lipopolysaccharide-induced hepatic microvascular dysfunction in mice. Shock. 2002 Aug;18(2):163-8. PMID: 12166781.
Saito M, Shima C, Takagi M, Ogino M, Katori M, Majima M. Enhanced exudation of fibrinogen into the perivascular space in acute inflammation triggered by neutrophil migration. Inflamm. Res. 2002 Jul;51(7):324-31. PMID: 12146723.
Hayashi I, Amano H, Yoshida S, Kamata K, Kamata M, Inukai M, Fujita T, Kumagai Y, Furudate S, Majima M. Suppressed angiogenesis in kininogen-deficiencies. Lab. Invest. 2002 Jul;82(7):871-80. PMID: 12118089.
Inamura H, Kurosawa M, Okano A, Kayaba H, Majima M. Expression of the interleukin-8 receptors CXCR1 and CXCR2 on cord-blood-derived cultured human mast cells. Int. Arch. Allergy Immunol. 2002 Jun;128(2):142-50. doi: 10.1159/000059405. PMID: 12065915.
Katada J, Majima M. AT(2) receptor-dependent vasodilation is mediated by activation of vascular kinin generation under flow conditions. Br. J. Pharmacol. 2002 Jun;136(4):484-91. doi: 10.1038/sj.bjp.0704731. PMID: 12055126. PMCID: PMC1573373.
Fujita M, Hayashi I, Yamashina S, Itoman M, Majima M. Blockade of angiotensin AT1a receptor signaling reduces tumor growth, angiogenesis, and metastasis. Biochem. Biophys. Res. Commun. 2002 Jun 7;294(2):441-7. doi: 10.1016/S0006-291X(02)00496-5. PMID: 12051731.
Matsumoto Y, Ito Y, Hayashi I, Majima M, Ishii K, Katagiri H, Kakita A. Effect of FR167653, a novel inhibitor of tumor necrosis factor-alpha and interleukin-1beta synthesis on lipopolysaccharide-induced hepatic microvascular dysfunction in mice. Shock. 2002 May;17(5):411-5. PMID: 12022763.
Amano H, Haysahi I, Yoshida S, Yoshimura H, Majima M. Cyclooxygenase-2 and adenylate cyclase/protein kinase A signaling pathway enhances angiogenesis through induction of vascular endothelial growth factor in rat sponge implants. Hum. Cell. 2002 Mar;15(1):13-24. PMID: 12126060.
Ishihara K, Kamata M, Hayashi I, Yamashina S, Majima M. Roles of bradykinin in vascular permeability and angiogenesis in solid tumor. Int. Immunopharmacol. 2002 Mar;2(4):499-509. PMID: 11962729.
Hayashi I, Amano H, Ishihara K, Kumagai Y, Yoshimura H, Majima MC. The role of kinin B1 in the plasma extravasation of carrageenin-induced pleurisy. Life Sci. 2002 Jan 11;70(8):937-49. PMID: 11853231.
Hirata M, Hayashi I, Yoshimura K, Ishii K, Soma K, Ohwada T, Kakita A, Majima M. Blockade of bradykinin B(2) receptor suppresses acute pancreatitis induced by obstruction of the pancreaticobiliary duct in rats. Br. J. Pharmacol. 2002 Jan;135(1):29-36. doi: 10.1038/sj.bjp.0704462. PMID: 11786477. PMCID: PMC1573123.
Ishihara K, Hayash I, Yamashina S, Majima M. A potential role of bradykinin in angiogenesis and growth of S-180 mouse tumors. Jpn. J. Pharmacol. 2001 Dec;87(4):318-26. PMID: 11829151.
Kamijo Y, Hayashi I, Soma K, Ohwada T, Majima M. Effect of neutral endopeptidase inhibitor on bradykinin-induced bronchoconstriction. Life Sci. 2001 Nov 21;70(1):1-15. PMID: 11764001.
Hatanaka K, Kawamura M, Murai N, Ogino M, Majima M, Ogino K, Harada Y. FR167653, a cytokine synthesis inhibitor, exhibits anti-inflammatory effects early in rat carrageenin-induced pleurisy but no effect later. J. Pharmacol. Exp. Ther. 2001 Nov;299(2):519-27. PMID: 11602662.
Majima M, Katori M. Effect of chronic blockade of the kallikrein-kinin system on the development of hypertension in rats. Hypertension. 2001 Oct;38(4):E21-3. PMID: 11641321.
Imasaki T, Kobayashi H, Hataishi R, Hayashi I, Tomita T, Majima M. Nitric oxide is generated in smooth muscle layer by neurokinin A and counteracts constriction in guinea pig airway. Nitric Oxide. 2001 Oct;5(5):465-74. doi: 10.1006/niox.2001.0361. PMID: 11587561.
Hayashi I, Ishihara K, Kumagai Y, Majima M. Proinflammatory characteristics of a nonpeptide bradykinin mimic, FR190997, in vivo. Br. J. Pharmacol. 2001 Aug;133(8):1296-306. doi: 10.1038/sj.bjp.0704208. PMID: 11498515. PMCID: PMC1621159.
Hayashi H, Ohno T, Nishiyama K, Boku K, Katori M, Majima M. Transient prevention of ethanol-induced gastric lesion by capsaicin due to release of endogenous calcitonin gene-related peptide in rats. Jpn. J. Pharmacol. 2001 Jul;86(3):351-354.
Suzuki M, Hayash I, Nara Y, Kumaga Y, Okamoto H, Hoka S, Majima M. Participation of cyclooxygenases in cutaneous thermal nociception under non-inflamed and inflamed conditions. Inflamm. Res. 2001 May;50(5):283-7.
Majima M, Amano H, Hayashi I. Endogenous prostaglandins and angiogenesis. JPS 2001 Apr;117(4):283-92.
Nishiyama K, Yao K, Iguci Y, Yamamoto K, Suzuki T, Sato K, Okamoto M, Majima M. Change in tissue kallikrein level in nasal wash after the administration of oxatomide in patients with nasal allergy. Am. J. Rhinol. 2001 Mar-Apr;15(2):105-8.
Katori M, Majima M, Hayashi I, Fujita T, Yamanaka M. Role of the renal kallikrein-kinin system in the development of salt-sensitive hypertension. Biol. Chem. 2001 Jan;382(1):61-4.
Boku K, Ohno T, Saeki T, Hayashi H, Hayashi I, Katori M, Murata T, Narumiya S, Saigenji K, Majima M. Adaptive cytoprotection mediated by prostaglandin I(2) is attributable to sensitization of CRGP-containing sensory nerves. Gastroenterology. 2001 Jan;120(1):134-43.
Yamaguchi K, Majima M, Katori M, Kakita A, Sugimoto K. Preferential consumption of coagulation factors I, V, and VIII in rat endotoxemia. Shock. 2000 Nov;14(5):535-43.
Fujita T, Kumagai Y, Ikeda Y, Inamura N, Iwata T, Ogino M, Majima M. Involvement of the renal kallikrein-kinin system in furosemide-induced natriuresis in rats. Jpn. J. Pharmacol. 2000 Oct;84(2):133-9.
Hayashi I, Majima M, Fujita T, Okumura T, Kumagai Y, Tomita N, Morishita R, Higaki J, Ogiwara T. In vivo transfer of antisense oligonucleotide against urinary kininase blunts deoxycorticosterone acetate-salt hypertension in rats. Br. J. Pharmacol. 2000 Oct;131(4):820-6.
Katori M, Majima M. Cyclooxygenase-2: its rich diversity of roles and possible application of its selective inhibitors. Inflamm. Res. 2000 Aug;49(8):367-92.
Imasaki T, Kobayashi H, Hanada N, Hayashi I, Tomita T, Majima M. Nitric Oxide Production in the Guinea Pig Airway by Neurokinin A. KMJ 2000 Aug;30(4): 260-7.
Muramatsu M, Katada J, Hattori M, Hayashi I, Majima M. Chymase mediates mast cell-induced angiogenesis in hamster sponge granulomas. Eur. J. Pharmacol. 2000 Aug 18;402(1-2):181-91.
Suzuki T, Katori M, Fujita T, Kumagai Y, Majima M. Involvement of the renal kallikrein-kinin system in K(+)-induced diuresis and natriuresis in anesthetized rats. Eur. J. Pharmacol. 2000 Jul 7;399(2-3):223-267.
Majima M, Hayashi I, Muramatsu M, Katada J, Yamashina S, Katori M. Cyclo-oxygenase-2 enhances basic fibroblast growth factor-induced angiogenesis through induction of vascular endothelial growth factor in rat sponge implants. Br. J. Pharmacol. 2000 Jun;130(3):641-9.
Saeki T, Ohno T, Boku K, Saigenji K, Katori M, Majima M. Mechanism of prevention by capsaicin of ethanol-induced gastric mucosal injury-a study in the rat using intravital microscopy. Aliment. Pharmacol. Ther. 2000 Apr;14 Suppl 1:135-44.
Muramatsu M, Katada J, Hayashi I, Majima M. Chymase as a proangiogenic factor. A possible involvement of chymase-angiotensin-dependent pathway in the hamster sponge angiogenesis model. J. Biol. Chem. 2000 Feb 25;275(8):5545-52.
Nakajima S, Ito H, Hayashi I, Kuribayashi Y, Okumura T, Yajima Y, Katori M, Majima M. Inhibition of kinin degradation on the luminal side of renal tubules reduces high blood pressure in deoxycorticosterone acetate salt-treated rats. Clin. Exp. Pharmacol. Physiol. 2000 Jan-Feb;27(1-2):80-7.
Majima M, Hayashi I, Inamura N, Fujita T, Ogino M. A nonpeptide mimic of bradykinin blunts the development of hypertension in young spontaneously hypertensive rats. Hypertension. 2000 Jan;35(1 Pt 2):437-42.
Li BY, Katori M, Kawamura M, Majima M, Yamashina S. Signal transduction mechanism of enhancement of ADP-induced aggregation by 5-hydrooxytryptamine in rabbit platelets. Asia Pacific Journal of Pharmacology 2000; 14:11-20.
Fujita T, Hayashi I, Kumagai Y, Inamura N, Majima M. Early increases in renal kallikrein secretion on administration of potassium or ATP-sensitive potassium channel blockers in rats. Br. J. Pharmacol. 1999 Nov;128(6):1275-83.
Muramatsu M, Katada J, Hayashi I, Majima M. [Involvement of chymase in angiogenesis in hamster sponge granulomas] JPS 1999 Oct;114 Suppl 1:48P-54P.
Fujita T, Hayashi I, Kumagai Y, Inamura N, Majima M. K+ loading, but not Na+ loading, and blockade of ATP-sensitive K+ channels augment renal kallikrein secretion. Immunopharmacology. 1999 Oct 15;44(1-2):169-75.
Majima M, Hayashi I, Fujita T, Ito H, Nakajima S, Katori M. Facilitation of renal kallikrein-kinin system prevents the development of hypertension by inhibition of sodium retention. Immunopharmacology. 1999 Oct 15;44(1-2):145-52.
Hayashi I, Fujita T, Majima M, Katori M. A secretory mechanism of renal kallikrein by a high potassium ion; a possible involvement of ATP-sensitive potassium channel. Immunopharmacology. 1999 Oct 15;44(1-2):49-55.
Ohno T, Katori M, Majima M, Saeki T, Boku K, Nishiyama K, Hayashi H, Saigenji K. Dilatation and constriction of rat gastric mucosal microvessels through prostaglandin EP2 and EP3 receptors. Aliment. Pharmacol. Ther. 1999 Sep;13(9):1243-50.
Ito H, Majima M, Nakajima S, Hayashi I, Katori M, Izumi T. Effect of prolonged administration of a urinary kinase inhibitor, ebelactone B on the development of deoxycorticosterone acetate-salt hypertension in rats. Br. J. Pharmacol. 1999 Feb;126(3):613-20.
Hayashi I, Majima M. Reduction of sodium deoxycholic acid-induced scratching behaviour by bradykinin B2 receptor antagonists. Br. J. Pharmacol. 1999 Jan;126(1):197-204.
Katori M, Majima M, Harada Y. Possible background mechanisms of the effectiveness of cyclooxygenase-2 inhibitors in the treatment of rheumatoid arthritis. Inflamm. Res. 1998 Oct;47 Suppl 2:S107-11.
Katori M, Majima M, Hayashi I. Crucial suppressive role of renal kallikrein-kinin system in development of salt-sensitive hypertension. Biol. Res. 1998;31(3):143-9.
Sugimoto K, Hirata M, Majima M, Katori M, Ohwada T. Evidence for a role of kallikrein-P6nin system in patients with shock after blunt trauma. Am. J. Physiol. 1998 Jun;274(6 Pt 2):R1556-60. PMID: 9608008.
Nakajima S, Majima M, Ito H, Hayashi I, Yajima Y, Katori M. Effects of a neutral endopeptidase inhibitor, BP102, on the development of deoxycorticosterone acetate-salt hypertension in kininogen-deficient Brown Norway Katholiek rats. Int. J. Tissue React. 1998 Feb;20(2):45-56. PMID: 9638501.
Katori M, Majima M. Preventive role of renal kallikrein-kinin system in the early phase of hypertension and development of new antihypertensive drugs. Adv. Pharmacol. 1998;44:147-224. PMID: 9547886.
Majima M, Isono M, Ikeda Y, Hayashi I, Hatanaka K, Harada Y, Katsumata O, Yamashina S, Katori M, Yamamoto S. Significant roles of inducible cyclooxygenase (COX)-2 in angiogenesis in rat sponge implants. Jpn. J. Pharmacol. 1997 Oct;75(2):105-14. PMID: 9414024.
Katori M, Majima M. Multiple roles of inducible cyclooxygenase-2 and its selective inhibitors. Folia Pharmacologica Japonica. 1997 Jun;109(6):247-258. PMID: 9253772.
Katori M, Majima M. Role of the renal kallikrein-kinin system in the development of hypertension. Immunopharmacology. 1997 Jun;36(2-3):237-42. PMID: 9228552.
Ito Y, Katori M, Majima M, Kakita A. Constriction of mouse hepatic venules and sinusoids by endothelins through ETB receptor subtype. Int. J. Microcirc. Clin. Exp. 1996 Sep-Oct;16(5):250-8. PMID: 8951523.
Majima M, Nishiyama K, Iguchi Y, Yao K, Ogino M, Ohno T, Sunahara N, Katoh K, Tatemichi N, Takei Y, Katori M. Determination of bradykinin-(1-5) in inflammatory exudate by a new ELISA as a reliable indicator of bradykinin generation. Inflamm. Res. 1996 Aug;45(8):416-23. PMID: 8872516.
Shindo M, Majima M, Ohno T, Sugimoto K, Ohwada T. Induction mechanism of small intestinal lesions caused by intravenous injection of endotoxin in rats. Surg. Today. 1996 Aug;26(8):610-7. PMID: 8855494.
Ogino M, Majima M, Kawamura M, Hatanaka K, Saito M, Harada Y, Katori M. Increased migration of neutrophils to granulocyte-colony stimulating factor in rat carrageenin-induced pleurisy: roles of complement, bradykinin, and inducible cyclooxygenase-2. Inflamm. Res. 1996 Jul;45(7):335-46.
Katori M, Nishiyama K, Iguchi Y, Majima M, Yao K. Reduction by a kallikrein inhibitor of the increased nasal airway resistance ofallergic patients after antigen challenge. Immunopharmacology. 1996 Jun;33(1-3):308-10.
Majima M, Katori M, Ogino M, Saito M, Sugimoto K, Adachi K, Ohno T, Sunahara N, Katoh K, Tatemichi N, Takei Y. Lack of contribution of circulatory kinin elevated by captopril to induce hypotension in normotensive and hypertensive rats. Immunopharmacology. 1996 Jun;33(1-3):291-3.
Hayashi H, Nishiyama K, Majima M, Katori M, Saigenji K. Role of endogenous substance P in ethanol-induced mucosal damage in the rat stomach. J Gastroenterol. 1996 Jun;31(3):314-22.
Majima M, Adachi K, Ohno T, Ogino M, Saito M, Kizuki K, Katsumata O,　Yamashina S, Katori M.　　Failure of the oxytocin-induced increase in secretion of urinary kallikrein in　young spontaneously hypertensive rats.　Jpn. J. Pharmacol. 1996 May;71(1):11-9.
Asari Y, Majima M, Sugimoto K, Katori M, Ohwada T.　　Release site of TNF alpha after intravenous and intraperitoneal injection of LPS from Escherichia coli in rats. Shock. 1996 Mar;5(3):208-12.
Arakawa M, Majima M, Nagai K, Goto F, Katori M. Role of tachykinins in enhancement of bradykinin-induced bronchoconstriction by captopril. Inflamm. Res. 1996 Feb;45(2):75-82.
Katori M, Majima M. Pivotal role of renal kallikrein-kinin system in the development of hypertension and approaches to new drugs based on this relationship. Jpn. J. Pharmacol. 1996 Feb;70(2):95-128. PMID; 8866749.
Kuribayashi Y, Katori M, Majima M, Yoshida K. Inhibitory effects of a phosphate diester of alpha-tocopherol and ascorbic acid (EPC-K1) on myocardial infarction in rats. Int. J. Tissue React. 1996 Feb;18(2-3):73-9. PMID: 9063769.
Harada Y, Hatanaka K, Kawamura M, Saito M, Ogino M, Majima M, Ohno T, Ogino K, Yamamoto K, Taketani Y, Yamamoto S, Katori M. Role of prostaglandin H synthase-2 in prostaglandin E2 formation in ratcarrageenin-induced pleurisy. Prostaglandins. 1996 Jan;51(1):19-33.
Shoda T, Hatanaka K, Saito M, Majima M, Ogino M, Harada Y, Nishijima M, Katori M, Yamamoto S. Induction of cyclooxygenase type-2 (COX-2) in rat endometrium at the peak of serum estradiol during the estrus cycle. Jpn. J. Pharmacol. 1995 Nov;69(3):289-291.
Majima M, Adachi K, Kuribayashi Y, Mizogami S, Katori M. Increase in vascular sensitivity to angiotensin II and norepinephrine after four-day infusion of 0.3 M sodium chloride in conscious kininogen-deficient brown Norway Katholiek rats. Jpn. J. Pharmacol. 1995 Oct;69(2):149-58.
Majima M, Ikeda Y, Kuribayashi Y, Mizogami S, Katori M, Aoyagi T. Ebelactone B, an inhibitor of urinary carboxypeptidase Y-like kininase, prevents the development of deoxycorticosterone acetate-salt hypertension in rats. Eur. J. Pharmacol. 1995 Sep 15;284(1-2):1-11.
Majima M, Katori M. Approaches to the development of novel antihypertensive drugs: crucial role of the renal kallikrein-kinin system. Trends Pharmacol Sci. 1995 Jul;16(7):239-46.
Adachi K, Majima M, Katori M, Nishijima M. Oxytocin-induced natriuresis mediated by the renal kallikrein-kinin system in anesthetized male rats. Jpn. J. Pharmacol. 1995 Mar;67(3):243-52.
Majima M, Li BY, Huang A, Katori M. Calcium mobilization in density subpopulations of rabbit washed platelets. Int J Tissue React. 1995 Feb;17(2):51-60.
Saito M, Majima M, Katori M, Sanjou Y, Suyama I, Shiokawa H, Koshiba K, Aoyagi T. Degradation of bradykinin in human urine by carboxypeptidase Y-like exopeptidase and neutral endopeptidase and their inhibition by ebelactone B and phosphoramidon. Int. J. Tissue React. 1995 Feb;17(5-6):181-90.
Ohno T, Katori M, Majima M, Hayashi H, Saigenji K. Different responses of arterioles and venules in rat gastric mucosal microcirculation to endothelin-1 and endothelin-3. J. Clin. Gastroenterol. 1995;21 Suppl 1:S56-S65. PMID: 8774992.
Katori M, Harada Y, Hatanaka K, Majima M, Kawamura M, Ohno T, Aizawa A, Yamamoto S. Induction of prostaglandin H synthase-2 in rat carrageenin-induced pleurisy and effect of a selective COX-2 inhibitor. Adv. Prostaglandin Thromboxane Leukot. Res. 1995 Feb;23:345-7.
Majima M, Mizogami S, Kuribayashi Y, Katori M, Oh-ishi S. Hypertension induced by a nonpressor dose of angiotensin II in kininogen-deficient rats. Hypertension. 1994 Jul;24(1):111-9.
Majima M, Kuribayashi Y, Ikeda Y, Adachi K, Kato H, Katori M, Aoyagi T. Diuretic and natriuretic effect of ebelactone B in anesthetized rats by inhibition of a urinary carboxypeptidase Y-like kininase. Jpn. J. Pharmacol. 1994 May;65(1):79-82.
Majima M, Yoshida O, Mihara H, Muto T, Mizogami S, Kuribayashi Y, Katori M, Oh-ishi S. High sensitivity to salt in kininogen-deficient brown Norway Katholiek rats. Hypertension. 1993 Nov;22(5):705-14.
Majima M, Shima C, Saito M, Kuribayashi Y, Katori M, Aoyagi T. Poststatin, a novel inhibitor of bradykinin-degrading enzymes in rat urine. Eur. J. Pharmacol. 1993 Mar 2;232(2-3):181-90.
Majima M, Sunahara N, Harada Y, Katori M. Detection of the degradation products of bradykinin by enzyme immunoassays as markers for the release of kinin in vivo. Biochem. Pharmacol. 1993 Feb 9;45(3):559-67.
Shima C, Majima M, Katori M. A stable metabolite, Arg-Pro-Pro-Gly-Phe, of bradykinin in the degradation pathway in human plasma. Jpn. J. Pharmacol. 1992 Oct;60(2):111-9.
Jin HY, Katori M, Majima M, Sunahara N. Increased secretion of glandular-kallikrein in the bronchial washings induced by intravenous injection of leukotriene C4 in guinea-pigs. Br. J. Pharmacol. 1992 Mar;105(3):632-8.
Majima M, Sunahara N, Uchida Y, Katori M. A useful and sensitive method for demonstration of the involvement of either kallikrein-kinin system in pathological states. Agents Actions1992;38 ( Pt 1):441-8.
Majima M, Jin HY, Katori M, Sunahara N. Increase in the kinin levels in the bronchial washings after intravenous injection of leukotriene C4 in guinea pigs. Agents Actions 1992;38 ( Pt 3):467-74.
Sugimoto K, Shindo M, Owada T, Majima M, Katori M. Plasma exudation by activated plasma kallikrein after intraperitoneal injection of lambda-carrageenin or endotoxin in rats. Agents Actions 1992;38 ( Pt 3):376-84.
Katori M, Majima M, Mohsin SS, Hanazuka M, Mizogami S, Oh-ishi S. Essential role of kallikrein-kinin system in suppression of blood pressure rise during the developmental stage of hypertension induced by deoxycorticosterone acetate-salt in rats. Agents Actions 1992;38 ( Pt 3):235-42.
Majima M, Katori M, Hanazuka M, Mizogami S, Nakano T, Nakao Y, Mikami R, Uryu H, Okamura R, Mohsin SS, et al. Suppression of rat deoxycorticosterone-salt hypertension by kallikrein-kinin system. Hypertension. 1991 Jun;17(6 Pt 1):806-13.
Katori M, Majima M, Odoi-Adome R, Sunahara N, Uchida Y. Evidence for the involvement of a plasma kallikrein-kinin system in the immediate hypotension produced by endotoxin in anaesthetized rats. Br. J. Pharmacol. 1989 Dec;98(4):1383-91.
Majima M, Ueno A, Sunahara N, Katori M. Measurement of des-Phe8-Arg9-bradykinin by enzyme-immunoassay--a useful parameter of plasma kinin release. Adv. Exp. Med. Biol. 1989;247B:331-5.
Majima M, Tani Y, Katori M. Degradation of Hageman factor by chymotrypsin-like protease released from rat mast cells during degranulation. Adv. Exp. Med. Biol. 1989;247A:487-92.
Katori M, Yong SJ, Majima M, Ueno A. Mechanism of bradykinin-induced nociceptive response. Adv. Exp. Med. Biol. 1989;247A:255-9.
Katori M, Majima M, Harada Y, Ueno A. A significant role of plasma kallikrein-kinin system in plasma exudation of rat carrageenin-induced pleurisy. Adv. Exp. Med. Biol. 1989;247A:137-44.
Katori M, Harada Y, Ueno A, Majima M, Oda T, Kawamura M. Modulation of plasma exudation by PGE2 and that of leukocyte migration by LTB4 in inflammatory models. Dermatologica. 1989;179 Suppl 1:60-3.
Majima M, Tani Y, Katori M. Loss of the activity of human coagulation factor XII by a chymotrypsin-like protease activated in rat mast cells during degranulation with compound 48/80. Thromb. Res. 1987 Jun 15;46(6):855-67.
Uchida Y, Majima M, Katori M. A method of determination of human plasma HMW and LMW kininogen levels by bradykinin enzyme immunoassay. Pharmacol. Res. Commun. 1986 Sep;18(9):831-46.