ニュース

最近の発表論文

最近の発表論文 2026年1月1日

Fujita T, Kamata M, Kumagai Y, Majima M. Involvement of the Renal Kallikrein–Kinin 
System in the Diuretic Action of a Thiazide 
Using a Crossover Design in Rats: 
An Exploratory Study. J Pharmacol. Pharmacotherapeutics　December 18, 2025. https://doi.org/10.1177/0976500X2514037382024年10月6日

Majima M, Matsuda Y, Watanabe SI, Ohtaki Y, Hosono K, Ito Y, Amano H. Prostanoids Regulate Angiogenesis and Lymphangiogenesis in Pathological Conditions. Cold Spring Harb Perspect Med. 2024 Apr 2:a041182. doi: 10.1101/cshperspect.a041182. Epub ahead of print. PMID: 38565267.

Hosono K, Yamashita A, Tanabe M, Ito Y, Majima M, Tsujikawa K, Amano H. Deletion of RAMP1 Signaling Enhances Diet-induced Obesity and Fat Absorption via Intestinal Lacteals in Mice. In Vivo. 2024 Jan-Feb;38(1):160-173. doi: 10.21873/invivo.13422. PMID: 38148085.

Majima M, Hosono K, Ito Y, Amano H, Nagashima Y, Matsuda Y, Watanabe SI, Nishimura H. A biologically active lipid, thromboxane, as a regulator of angiogenesis and lymphangiogenesis. Biomed Pharmacother. 2023 Jul;163:114831. doi: 10.1016/j.biopha.2023.114831. Epub 2023 May 8. PMID: 37150029.

Tanabe M, Hosono K, Yamashita A, Ito Y, Majima M, Narumiya S, Kusano C, Amano H. Deletion of TP signaling in macrophages delays liver repair following APAP-induced liver injury by reducing accumulation of reparative macrophage and production of HGF. Inflamm Regen. 2024 Oct 3;44(1):43. doi: 10.1186/s41232-024-00356-z. PMID: 39363292; PMCID: PMC11451145.

Thromboxane receptor, TP signaling enhances lymphangiogenesis acting on macrophages and T cells in the inflamed tissues. This is novel activity of TP signaling. TP signaling represents a promising target for controlling lymphangiogenesis.